TC-H 106 is a Class I HDAC (histone deacetylase) inhibitor of HDAC1, HDAC3, HDAC2 and HDAC8 with IC50 of 150, 370, 760 and 5000 nM respectively. TC-H 106 exhibits slow, tight-binding inhibitory activity. TC-H 106 displays no activity against Class II HDACs.
Estado de Materia
Soluble in DMSO (100 mM), ethanol (50 mM), DMF (~20 mg/ml), and 1:1solution of DMSO:PBS(pH7.2) (~0.5 mg/ml).
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