Molecular structure of TAPI-1, CAS Number: 171235-71-5
TAPI-1 (CAS 171235-71-5)
See product citations (15)
Alternate Names:
N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide
Application:
TAPI-1 is a structural analog of TAPI-0 with similar efficacy for the inhibition of MMPs and TACE
CAS Number:
171235-71-5
Molecular Weight:
499.60
Molecular Formula:
C26H37N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TAPI-1 is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of matrix metalloproteinases (MMPs) and TACE. TAPI-1 also blocks the shedding of several cell surface proteins such as IL-6 receptor, p60 TNF receptor, and p80 TNF receptor. TAPI-1 blocks constitutive and muscarinic receptor-stimulated sAAPalpha release in HEK 293 cells expressing M3 muscarinic receptors.
TAPI-1 (CAS 171235-71-5) References
- Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM17-like proteases. | Tanabe, Y., et al. 2008. Neurosci Lett. 444: 16-21. PMID: 18718504
- Lymphotoxin-alphabeta heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis. | Young, J., et al. 2010. Cytokine. 51: 78-86. PMID: 20356761
- Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells. | Seki, M., et al. 2010. FEBS Lett. 584: 2909-15. PMID: 20471383
- A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). | Breshears, LM., et al. 2012. J Biol Chem. 287: 32578-87. PMID: 22833676
- GRO-α/CXCR2 system and ADAM17 correlated expression in Sjögren's syndrome. | Lisi, S., et al. 2013. Inflammation. 36: 759-66. PMID: 23389772
- ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A. | Herzog, C., et al. 2014. J Biol Chem. 289: 13308-22. PMID: 24662289
- Pericellular proteolysis by matrix metalloproteinase-7 is differentially modulated by cholesterol sulfate, sulfatide, and cardiolipin. | Yamamoto, K., et al. 2014. FEBS J. 281: 3346-56. PMID: 24903600
- The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia. | Sun, X., et al. 2015. Oncotarget. 6: 35478-95. PMID: 26486084
- Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling. | Chen, Q., et al. 2016. Mol Cell Biol. 36: 2645-54. PMID: 27528615
- A high-sensitivity enzyme immunoassay for the quantification of soluble human semaphorin 4D in plasma. | Laber, A., et al. 2019. Anal Biochem. 574: 15-22. PMID: 30879960
- iNOS regulates activation of the NLRP3 inflammasome through the sGC/cGMP/PKG/TACE/TNF-α axis in response to cigarette smoke resulting in aortic endothelial pyroptosis and vascular dysfunction. | Liao, K., et al. 2021. Int Immunopharmacol. 101: 108334. PMID: 34768128
- ADAM17: A novel treatment target for aneurysms. | Bai, H., et al. 2022. Biomed Pharmacother. 148: 112712. PMID: 35158143
- In Silico and Experimental ADAM17 Kinetic Modeling as Basis for Future Screening System for Modulators. | Bienstein, M., et al. 2022. Int J Mol Sci. 23: PMID: 35163294
Inhibitor of:
ADAM10, ADAM20, ADAM24, ADAM26, ADAM7, ADAMTS-17, ADAMTS-8, ADAMTS-9, CPXM2, Enzyme, Filamin β, HB-EGF, hemicentin-2, Mast Cell Protease 4, Meprin A, MMP, MMP-10, MUP21, MUP9, MXRA5, NAALADL2, NET-7, Penumbra, PF4V1, SPPL3, SSc5D, TACE, TIMP-1, X11α, and ZIP9.Activator of:
ADAM28.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAPI-1, 1 mg | sc-222337 | 1 mg | $669.00 |