Substance P CAS: 33507-63-0
MF: C63H98N18O13S
MW: 1348
A neurokinin undecapeptide neurotransmitter and neuromodulator.

Substance P (CAS 33507-63-0)

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Solicitud: Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator
Número de CAS: 33507-63-0
Peso Molecular: 1348
Fórmula Molecular: C63H98N18O13S
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Substance P is a neurokinin neurotransmitter, which is characterized by the C-terminal sequence, Phe-X-Gly-Leu-Met-NH2. Substance P is known to be an important part of endocrine and exocrine gland secretion. In addition, Substance P is essential in smooth muscle contraction, pain, inflammatory response including vasodilation, plasma extravasation and mobilization of immune system cells. Alternate studies suggest that Substance P is a key factor in cancer cell proliferation and that inhibition of this component can induce apoptosis in cancer cells and decrease the steady state of Her2 (Neu) and EGFR. Substance P inhibits the phosphorylation of ERK, which results in a reduction of capsaicin-induced nociception. Substance P is an activator of NK-1R.


References

1. V Euler, U.S. and Gaddum, J.H. 1931. J. Physiol. 72: 74-87. PMID: 16994201
2. Mayordomo, C., et al. 2011. J Cell Physiol. PMID: 21604273
3. Komatsu, T., et al. 2011. Neuropharmacology. [Epub ahead of print]. PMID: 21601581

Uso :
Solubilize the product in an aqueous buffer or DMSO, then run the solution through a sterile filter to achieve a sterile end product.
Estado de Materia :
Solid
Secuencia :
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Solubilidad :
Soluble in water (1 mg/ml), DMSO, and 5% Acetic Acid.
ALMACENAMIENTO :
Store at -20° C
Densidad :
1.43 g/cm3
Indice de Refracción :
n20D 1.66
IC50 :
Neurokinin 1 receptor: IC50 = 0.12 nM (human); Neurokinin 3 receptor: IC50 = 125 nM (human)
Datos Ki :
Neurokinin 1 receptor: Ki= 1.1 nM (rat)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
WM2660000
PubChem CID :
36511
Indice de Merck :
14: 8863
Número MDL :
MFCD00076780
Número EC :
251-545-8
Registro Beilstein :
5153552
SMILES :
CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N

Descargar SDS (MSDS)

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