Sp4 Antibody (H-10): sc-515738

Sp4 Antibody (H-10) is a mouse monoclonal IgG2a antibody that detects Sp4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sp4 is a member of the Sp transcription factor family, which also includes Sp1, Sp2, and Sp3, and is characterized by a highly conserved DNA-binding domain featuring three zinc fingers at its C-terminus. This structural feature is crucial as Sp4 binds to specific DNA sequences known as GC boxes, which play a significant role in the regulation of gene expression. Unlike its family members, Sp4 is predominantly expressed in the brain, highlighting its potential importance in neural development and function. Additionally, Sp4 interacts with other transcription factors, influencing various signaling pathways and cellular processes. The ability of Sp4 to modulate gene expression in response to different stimuli underscores its significance in both normal physiology and disease states, making anti-Sp4 antibody (H-10) an essential tool for researchers studying transcriptional regulation and its implications in health and disease.

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Sp4 Antibody (H-10) References:

1. Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.  |  Lerner, LE., et al. 2005. J Biol Chem. 280: 20642-50. PMID: 15781457
2. Transcription factor SP4 is a susceptibility gene for bipolar disorder.  |  Zhou, X., et al. 2009. PLoS One. 4: e5196. PMID: 19401786
3. Sp4-dependent repression of neurotrophin-3 limits dendritic branching.  |  Ramos, B., et al. 2009. Mol Cell Neurosci. 42: 152-9. PMID: 19555762
4. Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling.  |  Saia, G., et al. 2014. J Neurochem. 129: 743-52. PMID: 24475768
5. Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning.  |  Sun, X., et al. 2015. Dev Neurobiol. 75: 93-108. PMID: 25045015
6. Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia.  |  Pinacho, R., et al. 2014. J Psychiatr Res. 58: 189-96. PMID: 25175639
7. Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects.  |  Pinacho, R., et al. 2015. Eur Neuropsychopharmacol. 25: 1650-1660. PMID: 26049820
8. Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons.  |  Nair, B., et al. 2016. Biochim Biophys Acta. 1863: 1-9. PMID: 26469128
9. The genetic polymorphisms in the SP4 gene and the risk of gastric cancer.  |  Cui, Y., et al. 2022. Future Oncol. 18: 3993-4004. PMID: 36346067
10. SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing.  |  Zhang, L., et al. 2024. Biochim Biophys Acta Mol Cell Res. 1871: 119841. PMID: 39222664

The preferred Sp4 antibody is Sp4 Antibody (B-1): sc-390124.