SERCA1 Antibody (IIH11): sc-53011

SERCA1 Antibody (IIH11) is a mouse monoclonal IgG1 antibody that detects SERCA1 in mouse, rat, rabbit, canine, and guinea pig samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SERCA1, a member of the sarcoplasmic or endoplasmic reticulum calcium ATPase (SERCA) family, plays a crucial role in muscle physiology by mediating calcium ion uptake into the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. Proper functioning of SERCA1 maintains low cytoplasmic calcium concentrations, preventing excessive muscle contraction and ensuring efficient muscle function. SERCA1 is predominantly expressed in type II (fast) skeletal muscle, where SERCA1 facilitates rapid calcium cycling necessary for quick muscle responses. SERCA1 undergoes alternative splicing, which can influence activity and regulation, making SERCA1 a key player in muscle health and performance. Anti-SERCA1 antibody (IIH11) serves as an invaluable tool for researchers studying muscle physiology, calcium signaling, and related pathologies, providing insights into mechanisms that govern muscle function and cellular homeostasis.

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SERCA1 Antibody (IIH11) References:

1. SERCA1 expression enhances the metabolic efficiency of improved contractility in post-ischemic heart.  |  O'Donnell, JM., et al. 2009. J Mol Cell Cardiol. 47: 614-21. PMID: 19744494
2. SERCA1 protein expression in muscle of patients with Brody disease and Brody syndrome and in cultured human muscle fibers.  |  Guglielmi, V., et al. 2013. Mol Genet Metab. 110: 162-9. PMID: 23911890
3. Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA1) by rutin derivatives.  |  Viskupicova, J., et al. 2015. J Muscle Res Cell Motil. 36: 183-94. PMID: 25467059
4. Rutin stimulates sarcoplasmic reticulum Ca(2+)-ATPase activity (SERCA1) and protects SERCA1 from peroxynitrite mediated injury.  |  Viskupicova, J., et al. 2015. Mol Cell Biochem. 402: 51-62. PMID: 25547066
5. SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.  |  Mázala, DA., et al. 2015. Am J Physiol Cell Physiol. 308: C699-709. PMID: 25652448
6. Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.  |  Zhao, Y., et al. 2015. Biochim Biophys Acta. 1852: 2042-7. PMID: 26170059
7. Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle.  |  Desmond, PF., et al. 2015. J Biol Chem. 290: 27854-67. PMID: 26405035
8. Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1).  |  Desmond, PF., et al. 2017. J Biol Chem. 292: 10961-10972. PMID: 28487373
9. SERCA1 Overexpression in Skeletal Muscle Attenuates Muscle Atrophy and Improves Motor Function in a Mouse Model of ALS.  |  Mázala, DAG., et al. 2024. J Neuromuscul Dis. 11: 315-326. PMID: 38217607
10. Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase.  |  Odermatt, A., et al. 1998. J Biol Chem. 273: 12360-9. PMID: 9575189

The preferred SERCA1/2/3 antibody is SERCA1/2/3 Antibody (B-7): sc-271669.