Senktide CAS: 106128-89-6
MF: C40H55N7O11S
MW: 841.97
A tachykinin NK-3 receptor agonist.

Senktide (CAS 106128-89-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 125ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Solicitud: Senktide is a tachykinin NK-3 receptor agonist
Número de CAS: 106128-89-6
Pureza: ≥95%
Peso Molecular: 841.97
Fórmula Molecular: C40H55N7O11S
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
loading

Senktide is shown to selectively interact with a tachykinin receptor subtype (SP-N) and can be used in studies to find out the regulation, distribution, and functional role of this receptor. This compound is also reported to be an NK-3R agonist and may cause behavior similar to serotonergic stimulation in murine models. NK-3R (tachykinin NK-3 receptors) have been noted to mediate bronchoconstriction in guinea pig lungs, and activation of these receptors by Senktide has also been shown to induce bronchoconstriction. Furthermore, this agent has demonstrated the ability to induce increased numbers of Fos-LI neurons in numerous regions of the guinea pig brain.


References

1. Laufer, R., et al. 1986. J. Biol. Chem. 261: 10257-10263. PMID: 2426259
2. Stoessl, A.J., et al. 1987. Neurosci. Lett. 80: 321-326. PMID: 2446214
3. Dam, T.V., et al. 1990. Brain Res. 506: 175-179. PMID: 1689199
4. Corboz, M.R., et al. 2010. Exp. Lung Res. 36: 509-521. PMID: 20939761

Estado de Materia :
Solid
Secuencia :
Succinyl-Asp-Phe-(N-Me)-Phe-Gly-Leu-Met-NH2
Solubilidad :
Soluble in methanol (25 mg/ml), ethanol (25 mg/ml), and DMSO (25 mg/ml).
ALMACENAMIENTO :
Store at -20° C
Punto de ebullición :
1262.64° C at 760 mmHg
Densidad :
1.29 g/cm3
Indice de Refracción :
n20D 1.58
IC50 :
Tachykinin receptor 3: EC5050 = 0.5 nM (rat); NK3 receptor: EC5050 = 3 nM (human); NK3 receptor: IC50 = 0.02 µM (human); achykinin receptor 3: IC50 = 0.01 µM (guinea pig)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
PubChem CID :
SMILES :
CC(C)C[[email protected]@H](C(=O)N[[email protected]@H](CCSC)C(=O)N)NC(=O)CNC(=O)[[email protected]](CC1=CC=CC=C1)N(C)C(=O)[[email protected]](CC2=CC=CC=C2)NC(=O)[[email protected]](CC(=O)O)NC(=O)CCC(=O)O

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

Necesita Adobe Acrobat Reader para ver de forma fiable,
imprimir y comentar el documento de PDF

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;