SCH 58261 (CAS 160098-96-4)
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SCH 58261 is a chemical compound that functions as a selective adenosine A2A receptor antagonist. It acts by binding to the adenosine A2A receptor and blocking its activation by endogenous adenosine. This interaction inhibits the downstream signaling pathways mediated by the adenosine A2A receptor, thereby modulating cellular responses. SCH 58261′s mechanism of action involves disrupting the binding of adenosine to its receptor, thereby preventing the receptor from initiating intracellular signaling. Sch 58261′s function in experimental applications involves studying the role of adenosine A2A receptor signaling in various physiological and pathological processes. By selectively antagonizing the adenosine A2A receptor, SCH 58261 allows the investigation of specific contributions for this receptor to cellular and molecular pathways without interference from other adenosine receptor subtypes.
SCH 58261 (CAS 160098-96-4) References
- Effects of SCH 58261, an adenosine A(2A) receptor antagonist, on quinpirole-induced turning in 6-hydroxydopamine-lesioned rats. Lack of tolerance after chronic caffeine intake. | Popoli, P., et al. 2000. Neuropsychopharmacology. 22: 522-9. PMID: 10731627
- SCH 58261 and ZM 241385 differentially prevent the motor effects of CGS 21680 in mice: evidence for a functional 'atypical' adenosine A(2A) receptor. | El Yacoubi, M., et al. 2000. Eur J Pharmacol. 401: 63-77. PMID: 10915839
- SCH 58261, an A(2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats. | Wardas, J., et al. 2001. Synapse. 41: 160-71. PMID: 11400182
- The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat. | Melani, A., et al. 2003. Brain Res. 959: 243-50. PMID: 12493612
- SCH 58261, a selective adenosine A2A receptor antagonist, decreases the haloperidol-enhanced proenkephalin mRNA expression in the rat striatum. | Wardas, J., et al. 2003. Brain Res. 977: 270-7. PMID: 12834887
- Synergistic effect of SCH 58261, an adenosine A2A receptor antagonist, and L-DOPA on the reserpine-induced muscle rigidity in rats. | Wardas, J. 2003. Pol J Pharmacol. 55: 155-64. PMID: 12926542
- The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia. | Melani, A., et al. 2006. Brain Res. 1073-1074: 470-80. PMID: 16443200
- Biaryl and heteroaryl derivatives of SCH 58261 as potent and selective adenosine A2A receptor antagonists. | Shah, U., et al. 2008. Bioorg Med Chem Lett. 18: 4199-203. PMID: 18562199
- Selective A2A receptor antagonist SCH 58261 modulates striatal oxidative stress and alleviates toxicity induced by 3-Nitropropionic acid in male Wistar rats. | Bortolatto, CF., et al. 2017. Metab Brain Dis. 32: 1919-1927. PMID: 28795281
- Assessment of Pharmacokinetics and Metabolism Profiles of SCH 58261 in Rats Using Liquid Chromatography-Mass Spectrometric Method. | Park, Y., et al. 2020. Molecules. 25: PMID: 32397307
- The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist. | Zocchi, C., et al. 1996. J Pharmacol Exp Ther. 276: 398-404. PMID: 8632302
- Cardiovascular pharmacology of the A2A adenosine receptor antagonist, SCH 58261, in the rat. | Monopoli, A., et al. 1998. J Pharmacol Exp Ther. 285: 9-15. PMID: 9535988
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCH 58261, 10 mg | sc-204272 | 10 mg | $195.00 | |||
SCH 58261, 50 mg | sc-204272A | 50 mg | $825.00 |