SB 218078 is the phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). SB 218078 acts as a potent inhibitor of Type I 5-phosphatase (Ins (1,4,5)P3 5-phosphatase) (IC50 ~150 nM). SB 218078 facilitates Ca2+ influx by sensitising Ins (1,4,5)P3-mediated activation of ICRAC. At higher concentrations, SB 218078 acts as an inhibitor of IP3R (Ins (1,4,5)P3 receptors). SB 218078 is also an inhibitor of checkpoint kinase 1(Chk1) with an IC50 value of 15 M. SB-218078 is a much weaker inhibitor of Cdc2 (Cdk 1)(IC50 = 250 nM) and PKC (IC50 = 1μM).
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