S-(−)-7-Desmethyl-8-nitro Blebbistatin (CAS 856925-75-2)
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S-(−)-7-Desmethyl-8-nitro Blebbistatin is a small molecule inhibitor with a specific affinity for myosin II, a motor protein involved in cellular contraction and motility. Research utilizing S-(−)-7-Desmethyl-8-nitro Blebbistatin focuses on elucidating the molecular mechanisms of myosin II action within cells and its role in processes such as cytokinesis, cell shape change, and muscle contraction. Due to its inhibitory effects on myosin II ATPase activity, the compound is valuable in studies of non-muscle cell motility, including the movement of cancer cells, which is a subject of interest in understanding metastasis. Additionally, it is used in the development of assays to study the mechanics of actomyosin contractility in vitro. The nitro group present in the molecule provides a distinctive characteristic that can be used to further modify the compound or to study its photodynamic properties under various experimental conditions.
S-(−)-7-Desmethyl-8-nitro Blebbistatin (CAS 856925-75-2) References
- Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. | Mayer, TU., et al. 1999. Science. 286: 971-4. PMID: 10542155
- Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction. | Abe, M., et al. 2003. J Biol Chem. 278: 47707-12. PMID: 14504290
- Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a 'tetraploidy checkpoint'. | Uetake, Y. and Sluder, G. 2004. J Cell Biol. 165: 609-15. PMID: 15184397
- Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. | Sakamoto, T., et al. 2005. Biochemistry. 44: 584-8. PMID: 15641783
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-(−)-7-Desmethyl-8-nitro Blebbistatin, 2.5 mg | sc-212797 | 2.5 mg | $342.00 |