Anti-RFC1 Anticuerpo B-5 es un monoclonal de ratón IgG2a κ RFC1 Anticuerpo, ver las 2 publicaciones, proporcionado como 200 µg/ml
producido contra los amino ácidos 848-1147 localizados en el C-terminus de origen RFC1 of human
RFC1 Anticuerpo (B-5) es recomendado para detectar RFC1 de human origen, mediante WB, IP, IF y ELISA
RFC1 Anticuerpo (B-5) es disponible conjugado a agarosa para IP; HRP para WB, IHC(P) y ELISA; y tanto a phycoerythrin como a FITC para IF, IHC(P) y FCM
también disponible conjugado a Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 o Alexa Fluor® 647 para WB (RGB), IF, IHC (P) y FCM
también disponible conjugado a Alexa Fluor® 680 o Alexa Fluor® 790 para WB (NIR), IF y FCM
Contacte con nosotros para recibir GRATIS 10 µg de muestra de RFC1 (B-5): sc-271656.
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for RFC1 Antibody (B-5) for WB applications. These reagents are now offered in bundles with RFC1 Antibody (B-5) (see ordering information below).
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possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
RFC1 Antibody (B-5) is a high quality monoclonal RFC1 antibody (also designated RFC1 antibody) suitable for the detection of the RFC1 protein of human origin. RFC1 Antibody (B-5) is available as both the non-conjugated anti-RFC1 antibody form, as well as multiple conjugated forms of anti-RFC1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Replication factor C (RFC) is an essential DNA polymerase accessory protein that is required for numerous aspects of DNA metabolism, including DNA replication, DNA repair and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction. All five of the RFC subunits share a set of related sequences (RFC boxes) that include nucleotide-binding consensus sequences. Four of the five RFC genes (including RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas the RFC1 subunit does not. RFC1 is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during FAS-mediated apoptosis. In addition, phosphorylation of the PCNA binding domain of RFC1 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibits DNA synthesis. The human RFC1 gene maps to chromosome 4p14 and encodes the RFC1 subunit.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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