Molecular structure of Ramelteon, CAS Number: 196597-26-9
Ramelteon (CAS 196597-26-9)
See product citations (3)
Alternate Names:
TAK-375
Application:
Ramelteon is a melatonin MT1/MT2 receptor agonist
CAS Number:
196597-26-9
Purity:
≥99%
Molecular Weight:
259.34
Molecular Formula:
C16H21NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Sedative, hypnotic melatonin MT1/MT2 receptor agonist.
Ramelteon (CAS 196597-26-9) References
- Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys. | Yukuhiro, N., et al. 2004. Brain Res. 1027: 59-66. PMID: 15494157
- TAK-375 Takeda. | Cajochen, C. 2005. Curr Opin Investig Drugs. 6: 114-21. PMID: 15675611
- Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. | Kato, K., et al. 2005. Neuropharmacology. 48: 301-10. PMID: 15695169
- Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat. | Fisher, SP., et al. 2008. J Pineal Res. 45: 125-32. PMID: 18298466
- Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells. | Imbesi, M., et al. 2008. Neurosci Lett. 439: 34-6. PMID: 18501512
- Melatonin receptor agonist ramelteon activates the extracellular signal-regulated kinase 1/2 in mouse cerebellar granule cells. | Imbesi, M., et al. 2008. Neuroscience. 155: 1160-4. PMID: 18664376
- Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings. | Wisor, JP., et al. 2009. Brain Res. 1296: 46-55. PMID: 19664610
- Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3H/HeN mice. | Rawashdeh, O., et al. 2011. Chronobiol Int. 28: 31-8. PMID: 21182402
- Chronic ramelteon treatment in a mouse model of Alzheimer's disease. | McKenna, JT., et al. 2012. Arch Ital Biol. 150: 5-14. PMID: 22786833
- Ramelteon Improves Post-traumatic Stress Disorder-Like Behaviors Exhibited by Fatty Acid-Binding Protein 3 Null Mice. | Yabuki, Y., et al. 2018. Mol Neurobiol. 55: 3577-3591. PMID: 28516430
- Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway. | Wang, J., et al. 2019. Free Radic Biol Med. 131: 345-355. PMID: 30553970
- Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury. | Wu, XL., et al. 2020. Acta Pharmacol Sin. 41: 1016-1024. PMID: 32107468
- Melatonin-Induced Postconditioning Suppresses NMDA Receptor through Opening of the Mitochondrial Permeability Transition Pore via Melatonin Receptor in Mouse Neurons. | Furuta, T., et al. 2022. Int J Mol Sci. 23: PMID: 35409182
- Shumian Capsule Improves the Sleep Disorder and Mental Symptoms Through Melatonin Receptors in Sleep-Deprived Mice. | Li, W., et al. 2022. Front Pharmacol. 13: 925828. PMID: 35873551
- Ramelteon Reduces Oxidative Stress by Maintenance of Lipid Homeostasis in Porcine Oocytes. | Sun, JT., et al. 2022. Antioxidants (Basel). 11: PMID: 36139716
Inhibitor of:
AANAT, and MEL-1B-R.Activator of:
MEL-1A-R, and MEL-1B-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ramelteon, 1 mg | sc-219934 | 1 mg | $190.00 |