PRMT7 Antibody (D-1): sc-166819
- PRMT7 Antibody (D-1) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 92-391 mapping near the N-terminus of PRMT7 of human origin
- recommended for detection of PRMT7 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PRMT7 Antibody (D-1) for WB applications. These reagents are now offered in bundles with PRMT7 Antibody (D-1) (see ordering information below).
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PRMT7 Antibody (D-1) is a mouse monoclonal IgG2a antibody that detects PRMT7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRMT7 is a critical enzyme involved in arginine methylation, an irreversible post-translational modification that plays a significant role in various cellular processes, including signal transduction, RNA transport, and RNA splicing. Anti-PRMT7 antibody (D-1) enables research into gene expression and protein interactions, which are essential for maintaining cellular homeostasis and responding to environmental cues. PRMT7 is localized in both the nucleus and cytoplasm, with moderate expression levels observed in adult brain and lung tissues, highlighting potential involvement in neurological and respiratory functions. PRMT7 features two methyltransferase domains, each with a putative S-adenosylmethionine-binding motif, and structural similarities to other PRMT family members, such as PRMT1 and PRMT5, suggest a conserved mechanism of action that could be crucial for understanding roles in health and disease. PRMT7 monoclonal antibody (D-1) serves as an invaluable tool for researchers investigating the functional implications of arginine methylation in various biological contexts.
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PRMT7 Antibody (D-1) References:
- PRMT7 as a unique member of the protein arginine methyltransferase family: A review. | Jain, K. and Clarke, SG. 2019. Arch Biochem Biophys. 665: 36-45. PMID: 30802433
- Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity. | Zhu, J., et al. 2021. Mol Cell. 81: 3171-3186.e8. PMID: 34171297
- Structure and Function of Protein Arginine Methyltransferase PRMT7. | Halabelian, L. and Barsyte-Lovejoy, D. 2021. Life (Basel). 11: PMID: 34440512
- PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation. | Ahn, BY., et al. 2022. Cell Mol Life Sci. 79: 99. PMID: 35089423
- An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression. | Shen, T., et al. 2022. Nat Commun. 13: 1232. PMID: 35264579
- The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. | Günes Günsel, G., et al. 2022. Nat Commun. 13: 1303. PMID: 35288557
- PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade. | Srour, N., et al. 2022. Cell Rep. 38: 110582. PMID: 35354055
- Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML. | Liu, C., et al. 2022. Cell Metab. 34: 818-835.e7. PMID: 35508169
- PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis. | Su, M., et al. 2024. J Proteome Res. 23: 1075-1087. PMID: 38376246
- Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy. | Ahn, BY., et al. 2024. Exp Mol Med. 56: 711-720. PMID: 38486105
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRMT7 Antibody (D-1) | sc-166819 | 200 µg/ml | $322.00 | |||
PRMT7 Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-534829 | 200 µg Ab; 40 µg BP | $361.00 | |||
PRMT7 Antibody (D-1): m-IgG2a BP-HRP Bundle | sc-546198 | 200 µg Ab; 10 µg BP | $361.00 |