PPARα Antibody (467D1a): sc-130640
- PPARα Antibody (467D1a) is a mouse monoclonal IgG1, cited in 11 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding an internal region of PPARα of human origin
- recommended for detection of PPARα of human origin by WB and IP
- See PPARα (H-2): sc-398394 for PPARα antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PPARα Antibody (467D1a). This work is in progress.
PPARα Antibody (467D1a) is a mouse monoclonal IgG1 antibody specifically designed to recognize the human Peroxisome Proliferator-Activated Receptor Alpha (PPARα), also known as NR1C1. Anti-PPARα antibody (467D1a) is raised against a recombinant protein corresponding to an internal region of human PPARα, ensuring precise binding to the target protein. PPARα is a pivotal nuclear hormone receptor that plays a significant role in regulating fatty acid metabolism, lipid homeostasis, and overall energy balance, making PPARα essential for maintaining metabolic health. By forming heterodimers with retinoid X receptors (RXRs), PPARα binds to specific PPAR-response elements (PPREs) in DNA, thereby modulating the transcription of genes involved in lipid metabolism and energy utilization. PPARα functionality is crucial in primary hepatocytes, where PPARα governs the expression of proteins necessary for fatty acid oxidation and overall metabolic processes. Additionally, PPARα interacts with other nuclear receptors such as LXRα and thyroid receptors, which can act as antagonists to PPARα binding with RXRα at PPREs, highlighting the intricate regulatory mechanisms governing lipid metabolism. PPARα monoclonal antibody (467D1a) demonstrates reliable reactivity with human PPARα in applications like western blotting (WB) and immunoprecipitation (IP), making PPARα (467D1a) antibody an indispensable tool for researchers studying PPARα-mediated pathways and gene regulation. Anti-PPARα antibody (467D1a) facilitates the exploration of PPARα′s role in various physiological and pathological conditions, including metabolic disorders, cardiovascular diseases, and liver function and is recommended for researchers studying the molecular underpinnings of metabolism and the development of targeted therapeutic strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PPARα Antibody (467D1a) | sc-130640 | 100 µg/ml | $339.00 |