PN-1 Antibody (4B3): sc-81717

PN-1 Antibody (4B3) is a mouse monoclonal IgG1 kappa light chain antibody that detects the PN-1 protein of mouse and rat origin, and to a lesser extent, human origin, by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-PN-1 antibody (4B3) targets protease nexin-1 (PN-1), a member of the serine protease inhibitor (serpin) superfamily, which plays a crucial role in regulating various physiological processes, including blood coagulation and tissue remodeling. PN-1 (4B3) monoclonal antibody recognizes PN-1 primarily located in the extracellular matrix and secreted by various cell types, where PN-1 functions to inhibit serine proteases such as thrombin and urokinase. This inhibition is vital for maintaining homeostasis in the nervous system, particularly during neural injury and repair processes, as PN-1 helps to prevent excessive proteolytic activity that could lead to tissue damage. Notably, an imbalance between PN-1 and thrombin has been implicated in the pathology of neurodegenerative diseases, including Alzheimer′s disease, highlighting PN-1′s importance in both normal physiological functions and disease states. With PN-1′s ability to modulate protease activity, this protein is essential for cellular invasiveness, matrix degradation, and tumor growth, making anti-PN-1 antibody (4B3) a valuable tool for researchers studying these critical biological processes.

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PN-1 Antibody (4B3) References:

1. Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone.  |  Wakida, N., et al. 2006. Kidney Int. 70: 1432-8. PMID: 16941024
2. Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.  |  Bouton, MC., et al. 2012. Blood. 119: 2452-7. PMID: 22234688
3. Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.  |  Vaillant, C., et al. 2015. PLoS One. 10: e0124870. PMID: 25901736
4. Protease nexin-1 regulates retinal vascular development.  |  Selbonne, S., et al. 2015. Cell Mol Life Sci. 72: 3999-4011. PMID: 26109427
5. Uptake of Plasmin-PN-1 Complexes in Early Human Atheroma.  |  Boukais, K., et al. 2016. Front Physiol. 7: 273. PMID: 27445860
6. Clearance of plasmin-PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta.  |  Boukais, K., et al. 2018. Cardiovasc Pathol. 32: 15-25. PMID: 29149696
7. Protease Nexin-1 in the Cardiovascular System: Wherefore Art Thou?  |  Madjene, C., et al. 2021. Front Cardiovasc Med. 8: 652852. PMID: 33869311
8. Protease nexin-1 deficiency increases mouse hindlimb neovascularisation following ischemia and accelerates femoral artery perfusion.  |  Selbonne, S., et al. 2021. Sci Rep. 11: 13412. PMID: 34183729
9. SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.  |  Zhang, J., et al. 2022. Cancer Lett. 524: 268-283. PMID: 34648881
10. Comprehensive genomic analysis of Burkholderia arboris PN-1 reveals its biocontrol potential against Fusarium solani-induced root rot in Panax notoginseng.  |  Yang, Y., et al. 2024. Curr Genet. 70: 4. PMID: 38555312

The preferred PN-1 antibody is PN-1 Antibody (C-12): sc-365650.