Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PLC β1 Antibody (D-8) is a high quality monoclonal PLC beta 1 antibody (also designated PLC β1 antibody) suitable for the detection of the PLC beta 1 protein of mouse, rat and human origin. PLC β1 Antibody (D-8) is available as both the non-conjugated anti-PLC beta 1 antibody form, as well as multiple conjugated forms of anti-PLC beta 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC b1, PLC b2, PLC b3, PLC b4, PLC g1, PLC g2, PLC d1, PLC d2 and PLCe. PLC g1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actin-regulatory protein villin is tyrosine phosphorylated and associates with PLC g1 in the brush border of intestinal epithelial cells. Villin regulates PLC g1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC g1 binds a1b1 integrin and modulates a1b1 integrin-specific adhesion. PLC g1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells. PLC g1 is rapidly activated in response to growth factor stimulation and plays an important role in regulating cell proliferation and differentiation. It may also have a protective function during cellular response to oxidative stress.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences