G3PP/PGP Antibody (E-10): sc-390883

G3PP/PGP Antibody (E-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects PGP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). G3PP/PGP (E-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. G3PP/PGP protein, also known as phosphoglycolate phosphatase, is a 321 amino acid enzyme that belongs to the HAD-like hydrolase superfamily and the CbbY/cbbZ/gph/yieH family. This enzyme plays a crucial role in regulating oxygen transport by modulating the levels of 2,3-diphosphoglycerate in red blood cells, which is essential for the proper release of oxygen from hemoglobin to tissues. G3PP/PGP is expressed in various tissues, including red blood cells, lymphocytes, and cultured fibroblasts, with the highest enzymatic activity found in skeletal and cardiac muscle. The gene encoding G3PP/PGP is located on human chromosome 16, a region associated with several genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome, highlighting the importance of G3PP/PGP in both normal physiology and disease states.

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G3PP/PGP Antibody (E-10) References:

1. Genetic polymorphism of human phosphoglycolate phosphatase (PGP).  |  Barker, RF. and Hopkinson, DA. 1978. Ann Hum Genet. 42: 143-51. PMID: 215071
2. An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.  |  Segerer, G., et al. 2016. Sci Rep. 6: 35160. PMID: 27731369
3. A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling.  |  Segerer, G., et al. 2018. Biochim Biophys Acta Mol Cell Biol Lipids. 1863: 584-594. PMID: 29524543
4. Mechanism of activation by anions of phosphoglycolate phosphatases from spinach and human red blood cells.  |  Rose, ZB., et al. 1986. J Biol Chem. 261: 10996-1002. PMID: 3015949
5. Glycolytic flux control by drugging phosphoglycolate phosphatase.  |  Jeanclos, E., et al. 2022. Nat Commun. 13: 6845. PMID: 36369173
6. Assignment of the human locus determining phosphoglycolate phosphatase (PGP) to chromosome 16.  |  Povey, S., et al. 1980. Ann Hum Genet. 43: 241-8. PMID: 6244770
7. Assignment of the human gene for phosphoglycolate phosphatase to chromosome 16.  |  Sparkes, RS., et al. 1980. Hum Genet. 54: 159-61. PMID: 6248449
8. Biochemical characterization of the genetic variants of human phosphoglycolate phosphatase (PGP).  |  Turner, VS. and Hopkinson, DA. 1981. Ann Hum Genet. 45: 121-7. PMID: 6274250
9. Population, formal genetics, and linkage relations of the phosphoglycolate phosphatase (PGP)--E.C.3.1.3.18.  |  Brink, W., et al. 1981. Hum Genet. 59: 386-8. PMID: 6277765
10. Phosphotransferase properties of human erythrocyte phosphoglycolate phosphatase.  |  Zecher, R., et al. 1982. Int J Biochem. 14: 771-4. PMID: 6290283
11. Purification, isolation and characterization of a phosphoglycolate phosphatase isoenzyme from human erythrocytes.  |  Zecher, R., et al. 1982. Int J Biochem. 14: 775-81. PMID: 6290284
12. Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of normal and anemic subjects.  |  Somoza, R. and Beutler, E. 1983. Blood. 62: 750-3. PMID: 6309283

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G3PP/PGP Antibody (E-10) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-G3PP/PGP Antibody (E-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G3PP/PGP Antibody (E-10) Specifications

Alternate Product Name: G3PP/PGP

Product Clone Name: E-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 57-70

Epitope Target: G3PP/PGP

Epitope Species: human

Product Reactivity/Detection: G3PP/PGP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for G3PP/PGP Antibody (E-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin