Molecular structure of Perifosine, CAS Number: 157716-52-4
Perifosine (CAS 157716-52-4)
See product citations (1)
Alternate Names:
KRX-0401
Application:
Perifosine is an alkylphospholipid which inhibits Akt activation and the anti-apoptotic MAPK pathway
CAS Number:
157716-52-4
Purity:
≥98%
Molecular Weight:
461.66
Molecular Formula:
C25H52NO4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Perifosine is employed in research focused on signal transduction pathways, particularly those involving the Akt signaling pathway. This compound is used extensively to study the mechanisms of action of kinase inhibitors and their role in modulating cellular processes such as growth, survival, and proliferation. Researchers utilize Perifosine to investigate its effects on various types of cells under different experimental conditions, aiding in the understanding of cellular responses to external stimuli. It is also a key tool in studying the biochemical pathways that lead to changes in cell behavior, providing valuable insights into the molecular basis of these processes. Additionally, Perifosine is used in investigations aimed at understanding how alterations in signal transduction pathways can affect cellular function and contribute to complex biological outcomes.
Perifosine (CAS 157716-52-4) References
- Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation. | Engel, JB., et al. 2008. Eur J Obstet Gynecol Reprod Biol. 141: 64-9. PMID: 18687514
- Perifosine: update on a novel Akt inhibitor. | Gills, JJ. and Dennis, PA. 2009. Curr Oncol Rep. 11: 102-10. PMID: 19216841
- Ocular side effects associated with imatinib mesylate and perifosine for gastrointestinal stromal tumor. | Dogan, SS. and Esmaeli, B. 2009. Hematol Oncol Clin North Am. 23: 109-14, ix. PMID: 19248974
- Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism. | Elrod, HA., et al. 2009. Mol Cancer Ther. 8: 2575-85. PMID: 19755515
- Enhancing perifosine's anticancer efficacy by preventing autophagy. | Sun, SY. 2010. Autophagy. 6: 184-5. PMID: 20023422
- Perifosine in renal cell carcinoma. | Srivastava, N. and Cho, DC. 2013. Expert Opin Investig Drugs. 22: 285-91. PMID: 23253151
- Perifosine as a potential novel anti-telomerase therapy. | Holohan, B., et al. 2015. Oncotarget. 6: 21816-26. PMID: 26307677
- Perifosine Mechanisms of Action in Leishmania Species. | López-Arencibia, A., et al. 2017. Antimicrob Agents Chemother. 61: PMID: 28096161
- Akt Pathway Inhibitors. | Uko, NE., et al. 2020. Curr Top Med Chem. 20: 883-900. PMID: 32091335
- Perifosine and vitamin D combination induces apoptotic and non-apoptotic cell death in endometrial cancer cells. | Karagul, MI., et al. 2020. EXCLI J. 19: 532-546. PMID: 32483402
- Perifosine, a Bioavailable Alkylphospholipid Akt Inhibitor, Exhibits Antitumor Activity in Murine Models of Cancer Brain Metastasis Through Favorable Tumor Exposure. | Taniguchi, K., et al. 2021. Front Oncol. 11: 754365. PMID: 34804943
- [Perifosine inhibits biofilm formation of Pseudomonas aeruginosa by interacting with PqsE protein]. | She, PF., et al. 2022. Zhonghua Yu Fang Yi Xue Za Zhi. 56: 192-196. PMID: 35184449
- Synergistic cytotoxicity of perifosine and ABT-737 to colon cancer cells. | Adamová, B., et al. 2023. J Cell Mol Med. 27: 76-88. PMID: 36523175
- Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor. | Jin, J., et al. 2023. Mol Immunol. 155: 27-43. PMID: 36682136
Inhibitor of:
ADAL, AI314180, AIDA, Akt, Akt1, Akt3, ALG-4, ANGEL2, ATP8A2, B430203M17Rik, B7RP-1, BTBD10, C12orf11, C6orf130, C9orf125, CCDC151, CCDC51, CDS1, CEACAM18, CLPTM1L, CMTM7, CWH43, DEP-1, DGK-δ, eIF4E, Ethanolamine kinase 2, EVT-2, FAM126B, FAM185A, FAM83B, FAM8A1, Fap-1, FAPP1, FKHRL1, GAP-assoc p62, GRAMD1C, GRAMD4, GRB10, HEPN1, ILKAP, INPP5B, INPP5F, KBTBD2, LOC646864, LOC728181, LOC729974, LPGAT1, MAGI-3, MBOAT1, MTMR10, MTMR15, NCYM, NYGGF4, Olfr585, PCYT2, PGs5, PHF14, PHLDA3, PIG-N, PIG11, PIPK I β, PKB Kinase, PKNβ, PLEKHA6, Polyoma virus middle T antigen, PRAS40, PRR14, PTP-MEG2, SAC1_Sac1, SBF2, Ser/Thr Protein Kinase, SMG1, SUR-5, TAPP1, TM4SF4, TMEM55A, TSPAN11, Type I 4-phosphatase, Type I 5-phosphatase, UEV3, WBSCR9, WDTC1, YadA, Ypk1, ZFYVE21, and ZPR1.Activator of:
14-3-3 σ, 4E-T, 5430411K18Rik, 6530418L21Rik, Atg14, Aut7, B430203M17Rik, BECN1L1, Clm3, CNOT1, DGS8, EF-2, EG435337, EG546638, eIF-4γ, eIF1AY, eIF3α, eIF3K, eIF4E2, FAM111B, FTS, GTSF1, KIAA0240, KIAA0317, LPPR2, MORN4, MTMR2, Ninein, PIG-C, PIK3IP1, PTEN, PTPρ, PTPRCAP, RIN1, SHIP-1, SSBP2, TINAGL1, Tip41, TPTE, and WDFY1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Perifosine, 5 mg | sc-364571 | 5 mg | $188.00 | |||
Perifosine, 10 mg | sc-364571A | 10 mg | $327.00 |