Molecular structure of Patulin, CAS Number: 149-29-1
Patulin (CAS 149-29-1)
See product citations (3)
Alternate Names:
4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one; Clavacin; Clairformin
Application:
Patulin is an inhibitor of protein prenylation
CAS Number:
149-29-1
Molecular Weight:
154.12
Molecular Formula:
C7H6O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Patulin, a mycotoxin, has been reported to contain antibiotic characteristics. This compound displays the ability to specifically inhibit Na+-K+ ATPase. In murine studies, Patulin was found to inhibit protein prenylation in cells. Mechanistic studies suggest that Patulin reduces incorporation of mevalonate into proteins and prevents protein transferase action, which is required for protein prenylation. Additional experiments show that this mycotoxin also inhibits cell-free microtubule polymerization by covalently reacting with thiol groups of microtubule proteins.
Patulin (CAS 149-29-1) References
- Chronology of patulin-induced alterations in membrane function of cultured renal cells, LLC-PK. | Riley, RT., et al. 1990. Toxicol Appl Pharmacol. 102: 128-41. PMID: 2153317
- Patulin: Mechanism of genotoxicity. | Glaser, N. and Stopper, H. 2012. Food Chem Toxicol. 50: 1796-801. PMID: 22425938
- Patulin-induced suicidal erythrocyte death. | Lupescu, A., et al. 2013. Cell Physiol Biochem. 32: 291-9. PMID: 23942252
- Patulin suppresses α1-adrenergic receptor expression in HEK293 cells. | Pillay, Y., et al. 2020. Sci Rep. 10: 20115. PMID: 33208818
- Factors influencing the removal of patulin by cysteine. | Ma, K., et al. 2021. Toxicon. 203: 51-57. PMID: 34626597
- Cardiotoxicity of patulin was found in H9c2 cells. | Zhang, B., et al. 2022. Toxicon. 207: 21-30. PMID: 34929212
- Involvement of caspase in patulin-induced hepatotoxicity in vitro and in vivo. | Zhang, B., et al. 2022. Toxicon. 206: 64-73. PMID: 34968565
- Reduction the contamination of patulin during the brewing of apple cider and its characteristics. | Wang, Z., et al. 2022. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 39: 1149-1162. PMID: 35343883
- A preliminary study on patulin contamination in spirit drinks. | Golge, O., et al. 2022. Food Addit Contam Part B Surveill. 15: 152-157. PMID: 35440278
- Patulin Induces Acute Kidney Injury in Mice through Autophagy-Ferroptosis Pathway. | Hou, Y., et al. 2022. J Agric Food Chem. 70: 6213-6223. PMID: 35543324
- Ultrasensitive detection of patulin based on a Ag+-driven one-step dual signal amplification. | Lu, X., et al. 2022. J Hazard Mater. 438: 129530. PMID: 35816803
- Patulin Detoxification by Recombinant Manganese Peroxidase from Moniliophthora roreri Expressed by Pichia pastoris. | Wang, S., et al. 2022. Toxins (Basel). 14: PMID: 35878178
- Patulin in tomatoes and the inhibitory capacity of their phenolic extracts against Penicillium expansum. | Rodrigues, MHP., et al. 2022. Food Res Int. 162: 112085. PMID: 36461334
- Inhibition of protein prenylation by patulin. | Miura, S., et al. 1993. FEBS Lett. 318: 88-90. PMID: 8436232
- Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. | Pfeiffer, E., et al. 1998. Carcinogenesis. 19: 1313-8. PMID: 9683194
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Patulin, 1 mg | sc-204833 | 1 mg | $73.00 | |||
Patulin, 5 mg | sc-204833A | 5 mg | $147.00 |