Molecular structure of Panobinostat, CAS Number: 404950-80-7
Panobinostat (CAS 404950-80-7)
See product citations (9)
Alternate Names:
Panobinostat is also known as LBH-589.
Application:
Panobinostat is a histone deacetylase (HDAC) inhibitor reported to inhibit human multiple myeloma cell lines.
CAS Number:
404950-80-7
Purity:
≥98%
Molecular Weight:
349.43
Molecular Formula:
C21H23N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Panobinostat (LBH589) is an HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. Panobinostat has potential applications in several different forms of cancer, in addition to spinal muscular atrophy and HIV therapy.
Panobinostat (CAS 404950-80-7) References
- Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. | Catley, L., et al. 2006. Blood. 108: 3441-9. PMID: 16728695
- Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells. | Fiskus, W., et al. 2006. Mol Cancer Ther. 5: 3096-104. PMID: 17172412
- The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. | Scuto, A., et al. 2008. Blood. 111: 5093-100. PMID: 18349321
- Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy. | Sasaki, D., et al. 2011. Haematologica. 96: 712-9. PMID: 21228036
- Panobinostat and Multiple Myeloma in 2018. | Yee, AJ. and Raje, NS. 2018. Oncologist. 23: 516-517. PMID: 29445026
- Panobinostat (LBH589) inhibits Wnt/β-catenin signaling pathway via upregulating APCL expression in breast cancer. | Qin, G., et al. 2019. Cell Signal. 59: 62-75. PMID: 30880222
- Panobinostat penetrates the blood-brain barrier and achieves effective brain concentrations in a murine model. | Homan, MJ., et al. 2021. Cancer Chemother Pharmacol. 88: 555-562. PMID: 34115161
- Panobinostat reverses HepaCAM gene expression and suppresses proliferation by increasing histone acetylation in prostate cancer. | Chen, E., et al. 2022. Gene. 808: 145977. PMID: 34592353
- Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer. | Wilson, AJ., et al. 2022. Neoplasia. 24: 63-75. PMID: 34933276
- Panobinostat enhances NK cell cytotoxicity in soft tissue sarcoma. | Lu, X., et al. 2022. Clin Exp Immunol. 209: 127-139. PMID: 35867577
- Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t(4;11) but promotes antagonistic effects in combination with MTX and 6MP. | Moreno, DA., et al. 2022. Med Oncol. 39: 216. PMID: 36175721
- Panobinostat inhibits breast cancer progression via Vps34-mediated exosomal pathway. | Wang, X. and Yin, X. 2023. Hum Cell. 36: 366-376. PMID: 36329365
- Panobinostat Synergistically Enhances the Cytotoxicity of Microtubule Destabilizing Drugs in Ovarian Cancer Cells. | Ovejero-Sánchez, M., et al. 2022. Int J Mol Sci. 23: PMID: 36361809
- The Combination of Panobinostat and Melphalan for the Treatment of Patients with Multiple Myeloma. | Gkotzamanidou, M., et al. 2022. Int J Mol Sci. 23: PMID: 36555311
- Histone Deacetylase Inhibitor Panobinostat Benefits the Therapeutic Efficacy of Oncolytic Herpes Simplex Virus Combined with PD-1/PD-L1 Blocking in Glioma and Squamous Cell Carcinoma Models. | Wu, Y., et al. 2022. Viruses. 14: PMID: 36560800
Inhibitor of:
1200013P24Rik, 4632411B12Rik, 4930502E18Rik, 4930557A04Rik, 5430421N21Rik, 6430550D23Rik, 9430015G10Rik9, A26C1B, A530032D15Rik, A630023A22Rik, AA416372, AB056442, Acatin, AGAP3, AKAP 1, ANKRD11, ANKRD20A5, ANKRD26, ASF1B, ASH2L, ASXL1, ASXL3, BAF250a, BAF57, BAF60a, BAGE4, BAHD1, BCoR, Bdf1, Blood Group H2, BORIS, BPTF, BRMS1L, BRWD1, Btnl1, c-Maf, C14orf43, cbp146, CDY2, CECR2, Chr-B, CHRAC17, Codanin-1, CPA6, CREST, CSN1, Dmap1, DNHD1, DNHD2, DPY-30, Dpy30, DUX3, DYDC2, Dynlt1d, Elongin C, Eso-1, EZI, FAM120AOS, FcRH5, FOXF2, FRYL, GAGE, GAGE12G, GAGE13, GAGE4, GATAD (GATA zinc finger domain containing), GATAD2A, Gm15070, Gm806, GSC, H2-A, H2-M10.1, H2afb2, H2al3, H2BFWT, H3.Y histone 1, H3.Y Histone 2, H60, HAT1, Hat2, Hbb-y, hCAP-D3, hCG_1982709, HDA1, HDA2, HDA4, HDA5, HDA6, HDA7, HDAC, HDAC1, HDAC11, HDAC2, HDAC3, HDAC6, HESL, Hils1, HiNF-P, Histone B, Histone cluster 1 H1C, Histone cluster 1 H1D, Histone cluster 1 H1E, Histone cluster 1 H2A, Histone cluster 1 H2AC, Histone cluster 1 H2AD, Histone cluster 1 H2AE, Histone cluster 1 H2AG, Histone cluster 1 H2AL, Histone cluster 1 H2AO, Histone cluster 1 H2B, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BE, Histone cluster 1 H2BF, Histone cluster 1 H2BO, Histone cluster 1 H3A, Histone cluster 1 H3B, Histone cluster 1 H3C, Histone cluster 1 H3E, Histone cluster 1 H3F, Histone cluster 1 H3I, Histone cluster 1 H3J, Histone cluster 1 H4, Histone cluster 1 H4G, Histone cluster 1 H4H, Histone cluster 1 H4K, Histone cluster 2 H2AA3, Histone cluster 2 H2AB, Histone cluster 2 H2AC, Histone cluster 2 H3A, Histone cluster 2 H3C, Histone cluster 2 H3C1, Histone cluster 2 H3C2, Histone cluster 2 H4, Histone H10, Histone H2A.Bbd, Histone H2A.F, Histone H2A.V, Histone H2A.X, Histone H2B.S, Histone H3, Histone H4, Histone Z, HLF, HoxA4, Ikaros, ING3, INO80D, Integrin, Integrin αV, Intelectin-b, INTS10, INTS8, INTS9, JAZF1, JMJD1A, kismet, L3MBTL2, Lacrein, LDOC1L, LIN-35, LIN-53, LOC100040657, LOC150383_2210021J22Rik, LOC340094, LOC388282, LOC646012, LOC665622, LOC729458, Lyl-1, lysine, Mael, MAGE-A11, MAGE-A2, MAGE-A9, MAGE-A9B, MAGE-B1, MAGE-B18, MAGE-B3, MAGE-B5, MAGE-E2, MAGE-F1, MAGE-G2, mage-k1, Mammaglobin A, Mi2-α, MIER1, MIER3, MLLT (Mixed Lineage Leukemia Translocated), Morc1, Morc3, MORF, MORF4L2, MRG15, MRGBP, mSin3A9, Msx-3, Mxi 1, NAP1L2, NAP1L5, NBPF24, NIF-1, NKAP, Npcd, Nup62-il4i1, NWD1, NY-REN-34, Obox3, Obox5, OCIAD1, Olr542, Olr556, Olr557, Olr577, Olr601, Olr610, Olr611, Olr614, Olr619, Olr634, Olr636, Olr639, Olr697, OTTMUSG00000016789, OTTMUSG00000016790, OTTMUSG00000016887, OTTMUSG00000018481, OTTMUSG00000018888, p130, p130 Cas, p150, p400, PAGE-2, pan-Acetyl, PATE2, PCDHB13, PCDHGA5, PCDHGA6, PEG3, PGs2_5730494M16Rik, PHF12, PHF2, PHF21A, PHF6, PI-9, Pi15, PLAC4, PRAMEF10, PRAMEF14, PRAMEF17, PRAMEF3, PRAMEF9, PRDM10, PRDM15, PRDM4, PRDM8, PWWP2B, RASSF1C, RBBP1, RBM25, RBM35B, RFXAP, RhD, RIZ, RP2, RP23-480B19.10, Rpd3, SAMD4B, SAP 130, SAP 25_Sap25, SAP 30L, SDS3, SETD5, SFMBT2, Siglec-5, SIM2, Sin3, Slfn11, SMARCD2, SMYD2, SNF2L, Snf5, SNURF, SPIN2, SPNS2, SPRN, SRRM5, STAMP2, STOX2, Subh2bv, T cell leukemia homeobox (TLX), TADA3L, TAF II p68, TAF II p70, TFPT, TIGD2, TIGD3, TNRC18, TOX3, Trav12d-3, TRRAP, TSPY9, TSSC4, TTC1, Tup1, UBN-1, USP49, V1RH18, VPS72, VSTM2A, WDR79, WIZ, WT1, YDJC, YEATS2, ZBP-89, ZBTB (Zinc finger BTB domain containing), ZBTB1, ZCWPW1, ZCWPW2, ZFP383, ZFP57, ZFP605, Zfp78, ZFP811, ZFP819, ZFP839, Zfp868, Zfp93, Zfp931, ZFP936, ZFP963, ZFP97, ZFY1, ZFY2, ZMYM6NB, ZMYND12, ZNF160, ZNF165, ZNF224, ZNF274, ZNF304, ZNF385A, ZNF536, ZNF57, ZNF649, ZNF711, ZNF740, and ZNHIT1.Activator of:
2900008C10Rik, 4930557A04Rik, ALKBH7, ASXL2, ATF-7IP, ATXN7L2, BAF53B, BAF60a, BAFL, BAZ2A, BRD3, BRD8, BRWD3, BTF3, C230099D08Rik, CBX7, CD38, CENP-A, CHD2, CHRAC15, CLAMP, CMTM2a, CSS2, D2Bwg1423e, DCHS1, DDO, DNAH14, DPF1, EAF1, EFO2, EG236663, EG385328, EG546205, EID-1, Erg, FAM188B2, FIV p27, FOXP3, GAGE3, GAGE7B, GAS41, H1T2, H2AL2, H2al2y, H2BFA, HDA4, HDA5, HHV-4 EBNA-2, HHV-4 LMP-1, HHV-4 ZEBRA, Histone cluster 1 H1B, Histone cluster 1 H2A, Histone cluster 1 H2AA2, Histone cluster 1 H2AC, Histone cluster 1 H2AE, Histone cluster 1 H2AG, Histone cluster 1 H2AK, Histone cluster 1 H2AM, Histone cluster 1 H2AN, Histone cluster 1 H2AO, Histone cluster 1 H2B, Histone cluster 1 H2BF, Histone cluster 1 H2BH, Histone cluster 1 H2BP, Histone cluster 1 H3E, Histone cluster 1 H3F, Histone cluster 1 H4, Histone cluster 1 H4F, Histone cluster 1 H4I, Histone cluster 1 H4L, Histone cluster 1 H4M, Histone cluster 2 H2AA1, Histone cluster 2 H3B, Histone cluster 2 H3C, Histone cluster 2 H3C2, Histone cluster 2 H4, Histone cluster 2 H4B, Histone cluster 3 H2ba, Histone cluster 4 H4, Histone H1B, Histone H1X, Histone H2A.V, Histone H2B, HIV gp24, HIV-1 p17, HIV-1 p55, HIV-1 Tat, HMG I, HMG-14, HMG-4, HoxD9, HPF1, JMJD2D, KIAA1688, KIAA1704, KIAA2026_9930021J03Rik, L3MBTL, LAGE-2A, Lamin A, LANPL, LDOC1L, LHFP, LIN-54, LOC100039210, LOC100041215, LOC128977, LOC646522, LOC646719, LOC729454, MAGE-A4, MAGE-A6, MAGE-G2, MAML3, MBTD1, Menin, MPHOSPH8, MRGBP, mSin3B, Mxi 1, MYSM1, NAP1L4, NFATc2IP, NY-ESO-1, Peregrin, periphilin 1, PHF20, PRAME like-3, PRAME like-6, PRAME like-7, PRAMEF12, PRAMEF14, PRAMEF16, PRAMEF17, PRAMEF18, R3HCC1, RASSF1, RASSF1F, RBA-1, RbAp46, RCOR2, rotavirus C vp4, SAP 18, SCML2, Sec24, SETD6, Siglec-9, SMARCD2, SPT16, SUV420H2, SWI/SNF-B, Swi3, SYT, TCFL5, TMED3, TMED5, Trimethyl Histone H3, u4/u6 snRNP, WSTF, XAGE-1, ZKSCAN4, ZNF295, ZNF33A, ZNF33B, ZNF345, ZNF396, ZNF469, ZNF498, ZNF553, ZNF597, ZNF671, ZNF806, and ZNF828.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Panobinostat, 10 mg | sc-208148 | 10 mg | $200.00 |