p-Troponin I-C Antibody (1G11): sc-66159
- p-Troponin I-C Antibody (1G11) is a mouse monoclonal IgG2b, cited in 1 publications, provided at 100 µg/ml
- raised against a phosphorylated form of cardiac Troponin I of human origin
- recommended for detection of a phosphorylated form of cardiac Troponin I of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Troponin I-C Antibody (1G11). This work is in progress.
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p-Troponin I-C Antibody (1G11) is a mouse monoclonal IgG2b antibody that detects p-Troponin I in human samples through western blotting (WB) and immunoprecipitation (IP) applications. p-Troponin I is a critical component of the troponin complex, which plays a vital role in the regulation of cardiac muscle contraction. p-Troponin I is primarily located in the cytoplasm of cardiac myocytes, where p-Troponin I interacts with actin and myosin to facilitate muscle contraction in response to calcium signaling. The precise localization of p-Troponin I is essential for effective excitation-contraction coupling, as p-Troponin I ensures that the contractile machinery is activated in a timely manner during each heartbeat. Additionally, p-Troponin I undergoes specific post-translational modifications, including phosphorylation, which can influence p-Troponin I interaction with other proteins and overall function in muscle contraction. Monitoring these modifications is crucial for understanding various cardiac pathologies, as elevated levels of phosphorylated Troponin I are often indicative of myocardial injury. By utilizing anti-p-Troponin I antibody (1G11), researchers can gain valuable insights into the dynamics of cardiac function and the molecular mechanisms underlying heart disease.
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p-Troponin I-C Antibody (1G11) References:
- Troponin I, C-reactive protein and fibrinogen levels in missed abortions. | Mollamahmutoğlu, L., et al. 2011. Clin Exp Obstet Gynecol. 38: 60-2. PMID: 21485729
- Structure and expression of the murine slow/cardiac troponin C gene. | Parmacek, MS. and Leiden, JM. 1989. J Biol Chem. 264: 13217-25. PMID: 2753913
- cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs. | Koppe, RI., et al. 1989. J Biol Chem. 264: 14327-33. PMID: 2760067
- Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease. | Nikorowitsch, J., et al. 2020. Biomolecules. 10: PMID: 32143410
- Establishment and Application of a Dual-Labeling Time-Resolved Fluorescence Immunoassay Method for Simultaneous Detection of the Troponin I-C Complex and Full-Size-Troponin I. | Huang, B., et al. 2020. Front Cardiovasc Med. 7: 596051. PMID: 33521060
- A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction. | Potter, JD., et al. 1995. J Biol Chem. 270: 2557-62. PMID: 7852318
- Structure and regulation of the mouse cardiac troponin I gene. | Ausoni, S., et al. 1994. J Biol Chem. 269: 339-46. PMID: 8276817
- Actin cytoskeleton. Setting the pace of cell movement. | Barkalow, K. and Hartwig, JH. 1995. Curr Biol. 5: 1000-2. PMID: 8542272
- Myosins: matching functions with motors. | Baker, JP. and Titus, MA. 1998. Curr Opin Cell Biol. 10: 80-6. PMID: 9484598
- A new look at thin filament regulation in vertebrate skeletal muscle. | Squire, JM. and Morris, EP. 1998. FASEB J. 12: 761-71. PMID: 9657517
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Troponin I-C Antibody (1G11) | sc-66159 | 100 µg/ml | $322.00 |