p-Tau Antibody (PHF-6): sc-32276
- p-Tau Antibody (PHF-6) is a mouse monoclonal IgG1 κ, cited in 9 publications, provided at 200 µg/ml
- raised against highly purified PHF-Tau preparation of human origin
- recommended for detection of Tau phosphorylated at Thr 231 of human origin by WB, IP, IF and IHC(P)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for p-Tau Antibody (PHF-6) for WB and IHC(P) applications. These reagents are now offered in bundles with p-Tau Antibody (PHF-6) (see ordering information below).
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p-Tau Antibody (PHF-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects p-Tau, phosphorylated at Thr 231, in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. p-Tau, also known as MAPT (microtubule-associated protein tau), is a 758 amino acid protein predominantly localized in the cytoplasm, cytoskeleton, and cell membrane, featuring four Tau/MAP repeats. p-Tau promotes microtubule assembly and stability, which maintains neuronal polarity and overall cellular integrity. p-Tau links microtubules with components of the neural plasma membrane, contributing to cytoskeletal plasticity, a vital aspect of neuronal function and adaptability. p-Tau undergoes various post-translational modifications, including phosphorylation, which can significantly impact function and interactions. Abnormal phosphorylation of p-Tau is a hallmark of neurodegenerative diseases, including Alzheimer′s disease, where p-Tau contributes to the formation of neurofibrillary tangles, leading to neuronal dysfunction and cell death. Anti-p-Tau antibody (PHF-6) serves as an invaluable tool for researchers studying these pathological processes and the role of p-Tau in neurodegeneration.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
p-Tau Antibody (PHF-6) References:
- Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer's Disease. | Reddy, PH. and Oliver, DM. 2019. Cells. 8: PMID: 31121890
- Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. | Zheng, J., et al. 2020. Cell Stem Cell. 26: 331-345.e6. PMID: 31978364
- Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. | Karikari, TK., et al. 2020. Lancet Neurol. 19: 422-433. PMID: 32333900
- Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease. | Barthélemy, NR., et al. 2020. J Exp Med. 217: PMID: 32725127
- Phosphorylated tau interactome in the human Alzheimer's disease brain. | Drummond, E., et al. 2020. Brain. 143: 2803-2817. PMID: 32812023
- Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes. | Mielke, MM., et al. 2021. JAMA Neurol. 78: 1108-1117. PMID: 34309632
- Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. | Thijssen, EH., et al. 2021. Lancet Neurol. 20: 739-752. PMID: 34418401
- Phosphorylated Tau in Alzheimer's Disease and Other Tauopathies. | Rawat, P., et al. 2022. Int J Mol Sci. 23: PMID: 36361631
- Plasma phosphorylated tau 217 in preclinical Alzheimer's disease. | Jonaitis, EM., et al. 2023. Brain Commun. 5: fcad057. PMID: 37013174
- Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology. | Ashton, NJ., et al. 2024. JAMA Neurol. 81: 255-263. PMID: 38252443
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Tau Antibody (PHF-6) | sc-32276 | 200 µg/ml | $322.00 | |||
p-Tau Antibody (PHF-6): m-IgG Fc BP-HRP Bundle | sc-536729 | 200 µg Ab; 10 µg BP | $361.00 | |||
p-Tau Antibody (PHF-6): m-IgGκ BP-HRP Bundle | sc-533890 | 200 µg Ab; 40 µg BP | $361.00 | |||
p-Tau Antibody (PHF-6): m-IgG1 BP-HRP Bundle | sc-544786 | 200 µg Ab; 20 µg BP | $361.00 |