p-IKKγ Antibody (36.Ser 376): sc-293135

p-IKKγ Antibody (36.Ser 376) is a mouse monoclonal IgG1 kappa light chain antibody that detects Ser 376 phosphorylated IKKγ of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). anti-p-IKKγ antibody (36.Ser 376) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. IKKγ, also known as NEMO, plays a crucial role in the NFkB signaling pathway, which is essential for regulating immune responses, inflammation, and cell survival. Located in the cytoplasm, IKKγ is a vital component of the IKK complex, which also includes IKKα and IKKβ. This complex is responsible for the phosphorylation of IκB proteins, leading to their degradation and the subsequent release of NFkB dimers that translocate to the nucleus to initiate transcription of target genes. The phosphorylation of IKKγ at Ser 376 enhances the stability and activity of the IKK complex, thereby amplifying the NFkB signaling cascade in response to pro-inflammatory stimuli. Understanding the dynamics of IKKγ phosphorylation and its interactions with other proteins in the signaling pathway is critical for elucidating the mechanisms underlying various diseases, including cancer and autoimmune disorders.

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p-IKKγ Antibody (36.Ser 376) References:

1. In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase.  |  Carter, RS., et al. 2003. J Biol Chem. 278: 19642-8. PMID: 12657630
2. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.  |  Verma, IM., et al. 1995. Genes Dev. 9: 2723-35. PMID: 7590248
3. NF-kappa B: a lesson in family values.  |  Thanos, D. and Maniatis, T. 1995. Cell. 80: 529-32. PMID: 7867060
4. CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.  |  Connelly, MA. and Marcu, KB. 1995. Cell Mol Biol Res. 41: 537-49. PMID: 8777433
5. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.  |  Malinin, NL., et al. 1997. Nature. 385: 540-4. PMID: 9020361
6. Identification and characterization of an IkappaB kinase.  |  Régnier, CH., et al. 1997. Cell. 90: 373-83. PMID: 9244310
7. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.  |  DiDonato, JA., et al. 1997. Nature. 388: 548-54. PMID: 9252186
8. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.  |  Song, HY., et al. 1997. Proc Natl Acad Sci U S A. 94: 9792-6. PMID: 9275204
9. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.  |  Zandi, E., et al. 1997. Cell. 91: 243-52. PMID: 9346241
10. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation.  |  Yamaoka, S., et al. 1998. Cell. 93: 1231-40. PMID: 9657155

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-IKKγ Antibody (36.Ser 376) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-p-IKKγ Antibody (36.Ser 376) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-IKKγ Antibody (36.Ser 376) Specifications

Alternate Product Name: NEMO

Product Clone Name: 36.Ser 376

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: Ser 376

Epitope Target: IKKγ

Epitope Species: human

Product Reactivity/Detection: Ser 376 phosphorylated IKKγ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for p-IKKγ Antibody (36.Ser 376): AC: Agarose, HRP: Horseradish Peroxidase

The preferred IKKγ antibody is IKKγ Antibody (B-3): sc-8032.