p-Fyn Antibody (D-1): sc-377555

p-Fyn Antibody (D-1) is a mouse monoclonal IgM kappa antibody that detects Thr 12 phosphorylated Fyn of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p-Fyn (D-1) antibody is available as the non-conjugated form. Fyn, a member of the Src family of non-receptor tyrosine kinases, plays a crucial role in various cellular processes, including signal transduction pathways that regulate cell proliferation, differentiation, and motility. Fyn is primarily localized in the cytoplasm and cell membrane, where Fyn is involved in the modulation of cellular signaling cascades. This localization is significant because Fyn interacts with various membrane-associated proteins and receptors, thereby influencing critical processes such as T-cell activation and synaptic signaling in neurons. The human Fyn gene, located on chromosome 6q21, encodes a 537 amino acid protein that is essential for T-cell receptor signaling, particularly in the context of immune responses. Understanding the functional implications of Fyn′s cellular localization helps researchers better elucidate Fyn′s role in health and disease, particularly in cancer and immune disorders.

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p-Fyn Antibody (D-1) References:

1. Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn.  |  Denny, MF., et al. 2000. Mol Cell Biol. 20: 1426-35. PMID: 10648627
2. Kinases of the Src family: structure and functions.  |  Tatosyan, AG. and Mizenina, OA. 2000. Biochemistry (Mosc). 65: 49-58. PMID: 10702640
3. Src kinase-mediated signaling in leukocytes.  |  Korade-Mirnics, Z. and Corey, SJ. 2000. J Leukoc Biol. 68: 603-13. PMID: 11073097
4. Selected glimpses into the activation and function of Src kinase.  |  Bjorge, JD., et al. 2000. Oncogene. 19: 5620-35. PMID: 11114743
5. SRC family kinases mediate epithelial Na+ channel inhibition by endothelin.  |  Gilmore, ES., et al. 2001. J Biol Chem. 276: 42610-7. PMID: 11560932
6. Nrf2 signaling and cell survival.  |  Niture, SK., et al. 2010. Toxicol Appl Pharmacol. 244: 37-42. PMID: 19538984
7. Prognostic Significance of Phosphorylated Fyn in Patients with Lung Adenocarcinoma after Lung Resection.  |  Nishikawa, S., et al. 2019. Ann Thorac Cardiovasc Surg. 25: 246-252. PMID: 31189776
8. Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non‑small cell lung cancer.  |  Tamari, S., et al. 2022. Oncol Rep. 48: PMID: 35959810
9. Heat shock protein amplification improves cerebellar myelination in the Npc1nih mouse model.  |  Gray, J., et al. 2022. EBioMedicine. 86: 104374. PMID: 36455410
10. Insights into Src kinase functions: structural comparisons.  |  Williams, JC., et al. 1998. Trends Biochem Sci. 23: 179-84. PMID: 9612082

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Fyn Antibody (D-1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Fyn Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Fyn Antibody (D-1) Specifications

Alternate Product Name: Fyn

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: Thr 12

Epitope Target: Fyn

Epitope Species: human

Product Reactivity/Detection: Thr 12 phosphorylated Fyn

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for p-Fyn Antibody (D-1): P: Blocking Peptide

The preferred Fyn antibody is Fyn Antibody (15): sc-434.