Molecular structure of NS-1619, CAS Number: 153587-01-0
NS-1619 (CAS 153587-01-0)
See product citations (2)
Alternate Names:
1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Application:
NS-1619 is a selective large conductance calcium activated potassium channel activator
CAS Number:
153587-01-0
Purity:
≥98%
Molecular Weight:
362.23
Molecular Formula:
C15H8F6N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A selective large conductance calcium activated potassium channel activator. In neutrophils, NS-1619 activation of BKCa channels increased alkalinization of phagocytic vacuoles
NS-1619 (CAS 153587-01-0) References
- Role of Ca(2+)-dependent K+ channels in erythrocyte lysate-induced contraction of rabbit cerebral artery. | Kim, CJ., et al. 1999. Neurol Res. 21: 705-11. PMID: 10555196
- Stimulus duration-dependent contribution of k(ca) channel activation and cAMP to hypoxic cerebrovasodilation. | Ben-Haim, G. and Armstead, WM. 2000. Brain Res. 853: 330-7. PMID: 10640631
- 5-(4'-Substituted-2'-nitroanilino)-1,2,3-triazoles as new potential potassium channel activators. I. | Biagi, G., et al. 2000. Eur J Med Chem. 35: 715-20. PMID: 10960187
- BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery. | Yamamura, H., et al. 2001. Br J Pharmacol. 132: 828-34. PMID: 11181423
- The large-conductance Ca2+-activated K+ channel is essential for innate immunity. | Ahluwalia, J., et al. 2004. Nature. 427: 853-8. PMID: 14985765
- The mitochondrial Ca2+-activated K+ channel activator, NS 1619 inhibits L-type Ca2+ channels in rat ventricular myocytes. | Park, WS., et al. 2007. Biochem Biophys Res Commun. 362: 31-36. PMID: 17698036
- Preconditioning with the BKCa channel activator NS-1619 prevents ischemia-reperfusion-induced inflammation and mucosal barrier dysfunction: roles for ROS and heme oxygenase-1. | Dai, H., et al. 2017. Am J Physiol Heart Circ Physiol. 313: H988-H999. PMID: 28822969
- Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle. | Edwards, G., et al. 1994. Br J Pharmacol. 113: 1538-47. PMID: 7534190
- NS 1619 activates BKCa channel activity in rat cortical neurones. | Lee, K., et al. 1995. Eur J Pharmacol. 280: 215-9. PMID: 7589189
- Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone. | Olesen, SP., et al. 1994. Eur J Pharmacol. 251: 53-9. PMID: 8137869
- A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca(2+)-activated K+ channels in bovine tracheal smooth muscle cells in culture. | Macmillan, S., et al. 1995. Br J Pharmacol. 116: 1656-60. PMID: 8564233
- NS 1619 activates Ca2+-activated K+ currents in rat vas deferens. | Huang, Y., et al. 1997. Eur J Pharmacol. 325: 21-7. PMID: 9151934
- Inhibition of guinea pig detrusor contraction by NS-1619 is associated with activation of BKCa and inhibition of calcium currents. | Sheldon, JH., et al. 1997. J Pharmacol Exp Ther. 283: 1193-200. PMID: 9399993
Inhibitor of:
MaxiK.Activator of:
RNF11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NS-1619, 5 mg | sc-200986 | 5 mg | $133.00 |