Neurokinin A CAS: 86933-74-6
MF: C50H80N14O14S
MW: 1133.33
An endogenous tachykinin agonist with preference for the NK-2R.

Neurokinin A (CAS 86933-74-6)

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Neurokinin A is rated 5.0 out of 5 by 1.
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Nombres Alternativos: Substance K; Neuromedin L
Solicitud: Neurokinin A is an endogenous tachykinin agonist with preference for the NK-2R
Número de CAS: 86933-74-6
Peso Molecular: 1133.33
Fórmula Molecular: C50H80N14O14S
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Neurokinin A is a member of the endogenous tachykinin agonist with preference for the NK-2R (NK-2 receptor) with greater potency as a bronchoconstrictor than Substance P (sc-201169). The comound has shown to be identical to substance K and neuromedin L1. Neurokinin A has been reported to effect reproduction by controlling at the hypothalamus level gonadotropin and prolactin secretion along with steroid secretion at the ovarian and gonadal level. An increase in inositol 1,4,5-trisphosphate (IP3) levels along with paralleled increase in intracellular free Ca2+ in BHK-21 cells with the NK-2R gene were stimulated with Neurokinin A. The compound has also been observed to induce contraction in muscle strips and single cells of the human sigmoid colon circular muscle. Neurokinin A has also been used to discover the location of tachykinin receptors.


References

1. Eistetter, H.R., et al. 1993. J. Cell. Biochem. 52: 84-91. PMID: 8391539
2. Debeljuk, L. and Lasaga, M. 1999. Peptides. 20: 285-299. PMID: 10422885
3. Cao, W., et al. 2000. Gastroenterology. 119: 51-61. PMID: 10889154

Estado de Materia :
Solid
Solubilidad :
Soluble in water (1 g/l) at 20° C, 10% acetonitrile / water (1 mg/ml), and 5% Acetic Acid.
ALMACENAMIENTO :
Store at -20° C
Punto de ebullición :
~1610.7° C at 760 mmHg (Predicted)
Densidad :
~1.3 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.58
Actividad Óptica :
α20/D -57.4°, c = 0.37 in 1 M AcOH
IC50 :
Neurokinin 2 receptor: IC50 = 1 nM (human); Neurokinin 1 receptor: IC50 = 3.5 nM (human); Neurokinin 3 receptor: IC50 = 45 nM (human)
Datos Ki :
Neurokinin 2 receptor: Ki= 0.71 nM (human); Neurokinin 1 receptor: Ki= 630 nM (human)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
PubChem CID :
55582
Número MDL :
MFCD00167560
SMILES :
CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N

Descargar SDS (MSDS)

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