NDR1 Antibody (YJ-7): sc-100404

NDR1 Antibody (YJ-7) is a mouse monoclonal IgG2a kappa light chain antibody that recognizes NDR1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NDR1 (YJ-7) antibody is available in a non-conjugated form, allowing for versatile experimental use. NDR1 plays a crucial role in regulating cell division and morphology, which is vital for maintaining normal cellular functions and preventing tumor progression. NDR1 is localized primarily in the nucleus, where NDR1 is involved in various signaling pathways that control cell cycle progression. This nuclear localization enables NDR1 to interact with transcription factors and other nuclear proteins, thereby influencing gene expression and cellular responses to external stimuli. NDR1 and NDR2 share a high degree of amino acid identity but exhibit distinct expression patterns, with NDR1 showing highest expression in the spleen, lung, and thymus, while NDR2 is predominantly expressed in the gastrointestinal tract. Both proteins are regulated by phosphorylation and interact with the calcium-binding protein S-100B, highlighting their importance in cellular signaling networks. NDR1 and NDR2 have been implicated in the HIV-1 life cycle, as these proteins are cleaved by the HIV-1 protease, which alters their enzymatic activity and subcellular localization. The genes encoding human NDR1 and NDR2 are located on chromosomes 6p21 and 12p11.23, respectively, further emphasizing their relevance in both normal physiology and disease states.

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NDR1 Antibody (YJ-7) References:

1. Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase.  |  Tamaskovic, R., et al. 2003. J Biol Chem. 278: 6710-8. PMID: 12493777
2. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein.  |  Stegert, MR., et al. 2004. J Biol Chem. 279: 23806-12. PMID: 15037617
3. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.  |  Devroe, E., et al. 2004. J Biol Chem. 279: 24444-51. PMID: 15067004
4. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.  |  Bichsel, SJ., et al. 2004. J Biol Chem. 279: 35228-35. PMID: 15197186
5. Seroepidemiologic study of toxocariasis and strongyloidiasis in institutionalized mentally retarded adults.  |  Huminer, D., et al. 1992. Am J Trop Med Hyg. 46: 278-81. PMID: 1558266

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NDR1 Antibody (YJ-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-NDR1 Antibody (YJ-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NDR1 Antibody (YJ-7) Specifications

Alternate Product Name: NDR1

Product Clone Name: YJ-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-466

Epitope Target: NDR1

Epitope Species: human

Product Reactivity/Detection: NDR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for NDR1 Antibody (YJ-7): N/A

The preferred NDR1 antibody is NDR1 Antibody (A-8): sc-365555.