N7-(2-Hydroxyethyl)guanine (CAS 53498-52-5)
Alternate Names:
2-Amino-1,7-dihydro-7-(2-hydroxyethyl)-6H-purin-6-one; 7-(2-Hydroxyethyl)guanine
CAS Number:
53498-52-5
Molecular Weight:
195.18
Molecular Formula:
C7H9N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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N7-(2-Hydroxyethyl)guanine (7-HEG) holds significant importance within the realm of synthetic biology. This compound represents a guanine derivative characterized by the presence of a hydroxyethyl group attached to the 7-position of the guanine ring. Its utilization has proven instrumental in unraveling the intricate mechanisms underlying gene expression regulation, transcriptional control, DNA repair, and ribosomal structure. Moreover, it has shed light on the interplay between guanine derivatives and enzyme activity, protein folding, and protein-protein interactions. Through its binding affinity to specific DNA sequences, N7-(2-Hydroxyethyl)guanine is believed to induce alterations in gene expression and other biochemical processes. Additionally, it has demonstrated the ability to interact with proteins and enzymes, consequently influencing their activity and structural conformation.
N7-(2-Hydroxyethyl)guanine (CAS 53498-52-5) References
- A gas chromatography/electron capture/negative chemical ionization high-resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring. | Wu, KY., et al. 1999. Chem Res Toxicol. 12: 722-9. PMID: 10458706
- Molecular dosimetry of endogenous and ethylene oxide-induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents. | Wu, KY., et al. 1999. Carcinogenesis. 20: 1787-92. PMID: 10469625
- Levels of N7-(2-hydroxyethyl)guanine as a molecular dosimeter of drug delivery to human brain tumors. | Bodell, WJ., et al. 2001. Neuro Oncol. 3: 241-5. PMID: 11584893
- Induction of lacI mutations in Big Blue Rat-2 cells treated with 1-(2-hydroxyethyl)-1-nitrosourea: a model system for the analysis of mutagenic potential of the hydroxyethyl adducts produced by 1,3-bis (2-chloroethyl)-1-nitrosourea. | Sprung, CN., et al. 2001. Mutat Res. 484: 77-86. PMID: 11733074
- Detection of C8-(1-hydroxyethyl)guanine in liver RNA and DNA from control and ethanol-treated rats. | Nakao, LS., et al. 2002. Chem Res Toxicol. 15: 1248-53. PMID: 12387621
- Repair of DNA alkylation products formed in 9L cell lines treated with 1-(2-chloroethyl)-1-nitrosourea. | Bodell, WJ. 2003. Mutat Res. 522: 85-92. PMID: 12517414
- Measurement of N7-(2'-hydroxyethyl)guanine in human DNA by gas chromatography electron capture mass spectrometry. | Kao, CY. and Giese, RW. 2005. Chem Res Toxicol. 18: 70-5. PMID: 15651851
- Activation of a beta-hydroxyalkylnitrosamine to alkylating agents: evidence for the involvement of a sulfotransferase. | Kroeger-Koepke, MB., et al. 1992. Cancer Res. 52: 3300-5. PMID: 1596888
- Rapid and sensitive on-line liquid chromatographic/tandem mass spectrometric determination of an ethylene oxide-DNA adduct, N7-(2-hydroxyethyl)guanine, in urine of nonsmokers. | Huang, CC., et al. 2008. Rapid Commun Mass Spectrom. 22: 706-10. PMID: 18257114
- Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation. | Marsden, DA., et al. 2009. Cancer Res. 69: 3052-9. PMID: 19276345
- Determination of N7-(2-hydroxyethyl)guanine by HPLC with electrochemical detection. | van Delft, JH., et al. 1991. Chem Biol Interact. 80: 281-9. PMID: 1954656
- Comparative analysis of urinary N7-(2-hydroxyethyl)guanine for ethylene oxide- and non-exposed workers. | Huang, CC., et al. 2011. Toxicol Lett. 202: 237-43. PMID: 21354284
- Preparation of electrophoric derivatives of N7-(2-hydroxyethyl)guanine, an ethylene oxide DNA adduct. | Allam, K., et al. 1990. J Chromatogr. 499: 571-8. PMID: 2324215
- Comparison of various immunochemical assays for the detection of ethylene oxide-DNA adducts with monoclonal antibodies against imidazole ring-opened N7-(2-hydroxyethyl)guanosine: application in a biological monitoring study. | van Delft, JH., et al. 1994. Carcinogenesis. 15: 1867-73. PMID: 7923579
- Detection of N7-(2-hydroxyethyl)guanine adducts in DNA and 9L cells treated with 1-(2-chloroethyl)-1-nitrosourea. | Ye, Q. and Bodell, WJ. 1997. J Chromatogr B Biomed Sci Appl. 694: 65-70. PMID: 9234849
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N7-(2-Hydroxyethyl)guanine, 100 mg | sc-470666 | 100 mg | $379.00 |