MFAP3 Antibody (B-10): sc-514605

MFAP3 Antibody (B-10) is a mouse monoclonal IgM kappa antibody that detects MFAP3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MFAP3 antibody (B-10) is available as the non-conjugated form. MFAP3 plays a crucial role in the formation and stabilization of microfibrils, which are essential components of the extracellular matrix that provide structural support to various tissues. These microfibrils can interact with elastin, influencing the mechanical properties of connective tissues. Proper functioning of MFAP3 is vital for maintaining the integrity of the extracellular matrix, and dysregulation has been implicated in several heritable diseases, including those affecting the cardiovascular and skeletal systems. Notably, MFAP3 gene is located near the fibrillin genes, which are associated with conditions such as Marfan syndrome and congenital contractural arachnodactyly, highlighting MFAP3′s importance in the context of microfibril-related pathologies. With an ability to detect MFAP3 across multiple species and applications, MFAP3 (B-10) antibody is an invaluable tool for researchers studying the role of microfibrils in health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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MFAP3 Antibody (B-10) References:

1. Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D.  |  Lausen, M., et al. 1999. J Biol Chem. 274: 32234-40. PMID: 10542261
2. Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung.  |  Schlosser, A., et al. 2006. Scand J Immunol. 64: 104-16. PMID: 16867155
3. Differential gene expression of 36-kDa microfibril-associated glycoprotein (MAGP-36/MFAP4) in rat organs.  |  Toyoshima, T., et al. 2008. Cell Tissue Res. 332: 271-8. PMID: 18322703
4. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression.  |  Andersen, DS. and Tapon, N. 2008. J Biol Chem. 283: 31256-67. PMID: 18765666
5. The gene for a human microfibril-associated glycoprotein is commonly deleted in Smith-Magenis syndrome patients.  |  Zhao, Z., et al. 1995. Hum Mol Genet. 4: 589-97. PMID: 7633408
6. Molecular cloning of the microfibrillar protein MFAP3 and assignment of the gene to human chromosome 5q32-q33.2.  |  Abrams, WR., et al. 1995. Genomics. 26: 47-54. PMID: 7782085
7. Structure of the human gene encoding the associated microfibrillar protein (MFAP1) and localization to chromosome 15q15-q21.  |  Yeh, H., et al. 1994. Genomics. 23: 443-9. PMID: 7835894
8. The gene for microfibril-associated protein-1 (MFAP1) is located several megabases centromeric to FBN1 and is not mutated in Marfan syndrome.  |  Liu, W., et al. 1997. Hum Genet. 99: 578-84. PMID: 9150721

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MFAP3 Antibody (B-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MFAP3 Antibody (B-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MFAP3 Antibody (B-10) Specifications

Alternate Product Name: MFAP3

Product Clone Name: B-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 280-301

Epitope Target: MFAP3

Epitope Species: human

Product Reactivity/Detection: MFAP3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MFAP3 Antibody (B-10): P: Blocking Peptide