MEK kinase-4 Antibody (K-7): sc-100396
- MEK kinase-4 Antibody (K-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant MEK kinase-4 of human origin
- recommended for detection of MEK Kinase-4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MEK kinase-4 Antibody (K-7). This work is in progress.
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MEK kinase-4 Antibody (K-7) is a mouse monoclonal IgG1 antibody that detects MEK kinase-4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MEK kinase-4 plays a crucial role in the mitogen-activated protein (MAP) kinase signaling cascade, which is essential for cellular responses to growth factors and other extracellular signals. Specifically, MEK kinase-4 activates the c-Jun N-terminal kinase (JNK) pathway, a critical pathway involved in regulating apoptosis, differentiation, and stress responses in cells. MEK kinase-4′s selective activation of JNK highlights its importance in mediating cellular responses to stress and inflammation, making MEK kinase-4 a significant target for research in cancer and other diseases where these pathways are dysregulated. Anti-MEK kinase-4 antibody (K-7) provides robust reactivity and versatility across multiple applications, serving as an invaluable tool for researchers studying the intricate signaling mechanisms that govern cell behavior.
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MEK kinase-4 Antibody (K-7) References:
- GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. | Chi, H., et al. 2004. EMBO J. 23: 1576-86. PMID: 15044949
- MEKK4 is an effector of the embryonic TRAF4 for JNK activation. | Abell, AN. and Johnson, GL. 2005. J Biol Chem. 280: 35793-6. PMID: 16157600
- Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. | Abell, AN., et al. 2005. Mol Cell Biol. 25: 8948-59. PMID: 16199873
- MEKK4 regulates developmental EMT in the embryonic heart. | Stevens, MV., et al. 2006. Dev Dyn. 235: 2761-70. PMID: 16894626
- MEKK4 signaling regulates filamin expression and neuronal migration. | Sarkisian, MR., et al. 2006. Neuron. 52: 789-801. PMID: 17145501
- The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems. | Bettinger, BT. and Amberg, DC. 2007. J Cell Biochem. 101: 34-43. PMID: 17348032
- MEKK4 sequesters RIP2 to dictate NOD2 signal specificity. | Clark, NM., et al. 2008. Curr Biol. 18: 1402-8. PMID: 18775659
- MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation. | Sun, BK., et al. 2011. Oncol Rep. 25: 537-44. PMID: 21152872
- MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear. | Haque, K., et al. 2016. J Neurosci. 36: 1347-61. PMID: 26818521
- MEKK4-mediated Phosphorylation of HOXA10 at Threonine 362 facilitates embryo adhesion to the endometrial epithelium. | Zhang, M., et al. 2022. Cell Death Discov. 8: 415. PMID: 36216824
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK kinase-4 Antibody (K-7) | sc-100396 | 100 µg/ml | $339.00 |