MEK-6 Antibody (D-8): sc-166727
- MEK-6 Antibody (D-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 297-315 at the C-terminus of MEK-6 of human origin
- recommended for detection of MEK-6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MEK-6 Antibody (D-8) for WB applications. These reagents are now offered in bundles with MEK-6 Antibody (D-8) (see ordering information below).
MEK-6 Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects MEK-6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MEK-6, also known as MKK-6, plays a crucial role in the activation of p38 MAP kinase, which is essential for various cellular responses, including inflammation, stress responses, and apoptosis. The activation of p38 MAP kinase by MEK-6 is particularly important because it mediates the cellular response to environmental stressors and is involved in the regulation of gene expression, cell differentiation, and survival. By phosphorylating specific threonine and tyrosine residues, MEK-6 ensures the proper functioning of the p38 MAP kinase pathway, which is vital for maintaining cellular homeostasis and responding to external stimuli. Anti-MEK-6 antibody (D-8) provides a reliable tool for researchers studying the intricate signaling pathways involving p38 MAP kinase, enabling a deeper understanding of its role in health and disease.
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MEK-6 Antibody (D-8) References:
- The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. | Min, X., et al. 2009. Structure. 17: 96-104. PMID: 19141286
- Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer. | Stramucci, L., et al. 2018. Cancers (Basel). 10: PMID: 29751559
- MKK6 Functions in Two Parallel MAP Kinase Cascades in Immune Signaling. | Lian, K., et al. 2018. Plant Physiol. 178: 1284-1295. PMID: 30185442
- The interaction of p38 with its upstream kinase MKK6. | Kumar, GS., et al. 2021. Protein Sci. 30: 908-913. PMID: 33554397
- Beiging Modulates Inflammatory Adipogenesis in Salt-Treated and MEK6-Transfected Adipocytes. | Kang, S. and Lee, M. 2021. Cells. 10: PMID: 34064531
- MEK6 Overexpression Exacerbates Fat Accumulation and Inflammatory Cytokines in High-Fat Diet-Induced Obesity. | Lee, S. and Lee, M. 2021. Int J Mol Sci. 22: PMID: 34948353
- MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation. | Romero-Becerra, R., et al. 2022. Elife. 11: PMID: 35971771
- PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6. | Chen, J., et al. 2023. Carcinogenesis. 44: 93-104. PMID: 36349938
- Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation. | Juyoux, P., et al. 2023. Science. 381: 1217-1225. PMID: 37708276
- Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. | Stein, B., et al. 1996. J Biol Chem. 271: 11427-33. PMID: 8626699
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK-6 Antibody (D-8) | sc-166727 | 200 µg/ml | $322.00 | |||
MEK-6 Antibody (D-8): m-IgG Fc BP-HRP Bundle | sc-537526 | 200 µg Ab; 10 µg BP | $361.00 | |||
MEK-6 Antibody (D-8): m-IgGκ BP-HRP Bundle | sc-534818 | 200 µg Ab; 40 µg BP | $361.00 | |||
MEK-6 (D-8) Neutralizing Peptide | sc-166727 P | 100 µg/0.5 ml | $69.00 |