MEK-3/6 Antibody (D-3): sc-133230
- MEK-3/6 Antibody (D-3) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 229-318 mapping at the C-terminus of MEK-3/6 of human origin
- recommended for detection of MEK-3 and MEK-6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MEK-3/6 Antibody (D-3) for WB and IHC(P) applications. These reagents are now offered in bundles with MEK-3/6 Antibody (D-3) (see ordering information below).
MEK-3/6 Antibody (D-3) is a mouse monoclonal IgG2b antibody that detects MEK-3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MEK-3, also known as MKK-3, plays a crucial role in the activation of the p38 MAP kinase pathway, which is essential for cellular responses to stress and inflammation. By phosphorylating specific threonine and tyrosine residues on p38 MAP kinase, MEK-3 facilitates the transmission of signals that regulate important biological processes such as cell differentiation, apoptosis, and the immune response. Proper functioning of MEK-3 is vital for maintaining cellular homeostasis, and dysregulation of this kinase has been implicated in various diseases, including cancer and inflammatory disorders. Anti-MEK-3/6 antibody (D-3) provides a reliable tool for researchers aiming to study the dynamics of the p38 MAP kinase pathway and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MEK-3/6 Antibody (D-3) References:
- MEK6 regulates human involucrin gene expression via a p38alpha - and p38delta -dependent mechanism. | Dashti, SR., et al. 2001. J Biol Chem. 276: 27214-20. PMID: 11454875
- The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. | Min, X., et al. 2009. Structure. 17: 96-104. PMID: 19141286
- CK2 is acting upstream of MEK3/6 as a part of the signal control of ERK1/2 and p38 MAPK during keratinocytes autocrine differentiation. | Isaeva, AR. and Mitev, VI. 2011. Z Naturforsch C J Biosci. 66: 83-6. PMID: 21476440
- Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory Myalgia. | Meng, H., et al. 2016. J Dent Res. 95: 1169-75. PMID: 27418173
- Beiging Modulates Inflammatory Adipogenesis in Salt-Treated and MEK6-Transfected Adipocytes. | Kang, S. and Lee, M. 2021. Cells. 10: PMID: 34064531
- Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation. | Ayala-Marin, YM., et al. 2021. Int J Mol Sci. 22: PMID: 34830095
- MEK6 Overexpression Exacerbates Fat Accumulation and Inflammatory Cytokines in High-Fat Diet-Induced Obesity. | Lee, S. and Lee, M. 2021. Int J Mol Sci. 22: PMID: 34948353
- Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway. | Peng, Y., et al. 2022. Chem Biol Interact. 361: 109983. PMID: 35569513
- PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6. | Chen, J., et al. 2023. Carcinogenesis. 44: 93-104. PMID: 36349938
- Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. | Stein, B., et al. 1996. J Biol Chem. 271: 11427-33. PMID: 8626699
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK-3/6 Antibody (D-3) | sc-133230 | 200 µg/ml | $322.00 | |||
MEK-3/6 Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-537359 | 200 µg Ab; 10 µg BP | $361.00 | |||
MEK-3/6 Antibody (D-3): m-IgGκ BP-HRP Bundle | sc-534604 | 200 µg Ab; 40 µg BP | $361.00 | |||
MEK-3/6 Antibody (D-3): m-IgG2b BP-HRP Bundle | sc-549864 | 200 µg Ab; 10 µg BP | $361.00 |