MBP Antibody (1.B.645): sc-71546

MBP Antibody (1.B.645) is a mouse monoclonal IgG2b light chain antibody that detects myelin basic protein (MBP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MBP is a crucial component of the myelin sheath in the central nervous system, playing a vital role in the insulation of axons, which is essential for the rapid transmission of electrical signals between neurons. The structure of MBP consists of a highly charged, flexible protein that interacts with lipids in the myelin membrane, contributing to the stability and integrity of the myelin sheath. Disruptions in MBP function or structure can lead to demyelinating diseases, such as multiple sclerosis, highlighting the significance of MBP in maintaining neuronal health. Anti-MBP antibody (1.B.645) serves as an invaluable tool for researchers studying myelination processes, neuronal signaling, and the pathophysiology of demyelinating disorders, providing insights into the molecular mechanisms underlying these critical biological functions.

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MBP Antibody (1.B.645) References:

1. Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines.  |  Maron, R., et al. 2002. Int Immunol. 14: 131-8. PMID: 11809732
2. Protein S-100B, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients.  |  Lamers, KJ., et al. 2003. Brain Res Bull. 61: 261-4. PMID: 12909296
3. Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP CaM-targets.  |  Polverini, E., et al. 2004. J Struct Biol. 148: 353-69. PMID: 15522783
4. Structural requirements for binding of myelin basic protein (MBP) peptides to MHC II: effects on immune regulation.  |  Mantzourani, ED., et al. 2005. Curr Med Chem. 12: 1521-35. PMID: 15974985
5. Visualization of axonal degeneration after optic nerve lesion in rat by immunohistochemical labelling for myelin basic protein (MBP).  |  Schmidt-Kastner, R., et al. 1994. Restor Neurol Neurosci. 6: 145-9. PMID: 21551741
6. Multiple sites of the cleavage of 17- and 19-mer encephalytogenic oligopeptides corresponding to human myelin basic protein (MBP) by specific anti-MBP antibodies from patients with systemic lupus erythematosus.  |  Bezuglova, AM., et al. 2012. Peptides. 37: 69-78. PMID: 22781164
7. Immunochemical cross-reactivity between intact purified myelin basic protein (MBP) and the synthetic encephalitogenic peptide S49.  |  Lazarus, KJ., et al. 1984. Neurochem Res. 9: 1295-308. PMID: 6209588
8. Human myelin basic protein (MBP) epitopes recognized by mouse MBP-selected T cell lines from multiple sclerosis patients.  |  Chou, YK., et al. 1994. J Neuroimmunol. 49: 45-50. PMID: 7507496
9. Thymic expression of myelin basic protein (MBP). Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP.  |  Fritz, RB. and Zhao, ML. 1996. J Immunol. 157: 5249-53. PMID: 8955169
10. Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft.  |  Lee, C., et al. 1998. J Exp Med. 187: 1505-16. PMID: 9565642

The preferred MBP antibody is MBP Antibody (F-6): sc-271524.