Legumain Antibody (F-10): sc-271312
- Legumain Antibody (F-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 60-100 near the N-terminus of Legumain of human origin
- recommended for detection of precursor and mature Legumain of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Legumain Antibody (F-10) for WB applications. These reagents are now offered in bundles with Legumain Antibody (F-10) (see ordering information below).
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SEE ALSO...
Legumain Antibody (F-10) is a mouse monoclonal IgG1 antibody that detects Legumain in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Legumain, also known as LGMN, AEP (asparaginyl endopeptidase), or PRSC1, is a 433 amino acid protein that plays a crucial role as a cysteine protease, specifically catalyzing the hydrolysis of asparaginyl and aspartyl bonds. This enzymatic activity is particularly important for processing proteins within lysosomal and endosomal systems, where Legumain is primarily localized. By facilitating the presentation of bacterial proteins on MHC class II molecules, Legumain is integral to the immune response, influencing how the body recognizes and responds to pathogens. Furthermore, multiple isoforms of Legumain, resulting from alternative splicing, add complexity to its functional roles in various biological processes. Notably, overexpression of Legumain has been linked to the development of solid tumors, highlighting potential involvement in carcinogenesis. Anti-Legumain antibody (F-10) is an essential tool for researchers investigating the multifaceted roles of Legumain in health and disease.
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Legumain Antibody (F-10) References:
- Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin. | Solberg, R., et al. 2015. Biol Chem. 396: 71-80. PMID: 25205715
- Knockdown of Legumain Suppresses Cervical Cancer Cell Migration and Invasion. | Meng, F. and Liu, W. 2016. Oncol Res. 23: 7-12. PMID: 26802645
- Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis. | Lunde, NN., et al. 2017. Atherosclerosis. 257: 216-223. PMID: 27940038
- Legumain suppresses OxLDL-induced macrophage apoptosis through enhancement of the autophagy pathway. | Sun, W., et al. 2018. Gene. 652: 16-24. PMID: 29414692
- Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor β1. | Ren, YC., et al. 2020. J Mol Med (Berl). 98: 863-874. PMID: 32415356
- Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. | Zhao, T., et al. 2021. Invest New Drugs. 39: 337-347. PMID: 32978718
- Legumain protease-sheddable PEGylated, tuftsin-modified nanoparticles for selective targeting to tumour-associated macrophages. | Liang, DS., et al. 2022. J Drug Target. 30: 82-93. PMID: 33775195
- Legumain knockout improves repeated corticosterone injection-induced depression-like emotional and cognitive deficits. | Zhang, W., et al. 2021. Behav Brain Res. 413: 113464. PMID: 34265317
- Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma. | Tang, Q., et al. 2022. Exp Eye Res. 224: 109221. PMID: 36041510
- The Asparaginyl Endopeptidase Legumain: An Emerging Therapeutic Target and Potential Biomarker for Alzheimer's Disease. | Song, M. 2022. Int J Mol Sci. 23: PMID: 36142134
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Legumain Antibody (F-10) | sc-271312 | 200 µg/ml | $322.00 | |||
Legumain Antibody (F-10): m-IgG Fc BP-HRP Bundle | sc-537609 | 200 µg Ab; 10 µg BP | $361.00 | |||
Legumain Antibody (F-10): m-IgGκ BP-HRP Bundle | sc-534925 | 200 µg Ab; 40 µg BP | $361.00 | |||
Legumain Antibody (F-10): m-IgG1 BP-HRP Bundle | sc-545258 | 200 µg Ab; 20 µg BP | $361.00 | |||
Legumain (F-10) Neutralizing Peptide | sc-271312 P | 100 µg/0.5 ml | $69.00 |