LDH-A Antibody (F-3): sc-137244

LDH-A Antibody (F-3) is a mouse monoclonal IgG1 antibody that detects lactate dehydrogenase A (LDH-A) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LDH-A plays a crucial role in cellular metabolism by catalyzing the conversion of pyruvate to L-lactate during anaerobic glycolysis, a process vital for energy production in tissues experiencing low oxygen levels, such as muscle during intense exercise. This enzymatic activity maintains the balance of NAD+/NADH and supports ATP regeneration, essential for cellular functions. LDH-A serves as a significant biomarker for various conditions, including germ cell tumors, and expression patterns provide insights into tissue-specific metabolic adaptations. The LDH-A gene is located on chromosome 11, and mutations or deficiencies can lead to metabolic disorders such as exertional myoglobinuria, highlighting LDH-A′s critical role in human health. Anti-LDH-A antibody (F-3) is an invaluable tool for researchers studying metabolic pathways, cancer biology, and related fields.

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LDH-A Antibody (F-3) References:

1. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.  |  Fantin, VR., et al. 2006. Cancer Cell. 9: 425-34. PMID: 16766262
2. LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis.  |  Wang, ZY., et al. 2012. Breast Cancer Res Treat. 131: 791-800. PMID: 21452021
3. LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo.  |  Langhammer, S., et al. 2011. Target Oncol. 6: 155-62. PMID: 21660559
4. Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.  |  Rizwan, A., et al. 2013. Clin Cancer Res. 19: 5158-69. PMID: 23833310
5. Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells.  |  Yang, Y., et al. 2014. Oncotarget. 5: 11886-96. PMID: 25361010
6. LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer.  |  Jiang, F., et al. 2016. Biochem Biophys Res Commun. 469: 985-92. PMID: 26721441
7. A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer.  |  Boison, D., et al. 2016. Colloids Surf B Biointerfaces. 147: 387-396. PMID: 27559997
8. Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR.  |  Varma, G., et al. 2021. NMR Biomed. 34: e4560. PMID: 34086382
9. Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma.  |  Franczak, MA., et al. 2023. Int J Mol Sci. 24: PMID: 37175477
10. The Chemokine CXCL7 is Correlated with LDH-A and Predicts the Prognosis of Patients with Colorectal Cancer.  |  Liang, H., et al. 2024. Front Biosci (Landmark Ed). 29: 166. PMID: 38682188

The preferred LDH-A antibody is LDH-A Antibody (E-9): sc-137243.