κB-Ras1 Antibody (184C278): sc-52915
- κB-Ras1 Antibody (184C278) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 96-113 of κB-Ras1 of human origin
- recommended for detection of κB-Ras1 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for κB-Ras1 Antibody (184C278). This work is in progress.
κB-Ras1 Antibody (184C278) is a mouse monoclonal IgG1 antibody raised against human κB-Ras1, a critical regulator of NFκB signaling pathways. Anti-κB-Ras1 antibody (184C278) recognizes an epitope within the κB-Ras1 immunogen sequence and demonstrates broad species cross-reactivity, detecting κB-Ras1 in mouse, rat, and human samples through Western blotting (WB) and immunoprecipitation (IP) applications. As a member of the small guanosine triphosphatases family, κB-Ras1 maintains precise cytoplasmic localization where κB-Ras1 interacts with IκB proteins, particularly IκB-α and IκB-β, to regulate their degradation kinetics. κB-Ras1′s ability to stabilize IκB-β proves especially significant, as this interaction helps control NFκB activation - a transcription factor governing genes involved in immune response, cell proliferation, and survival. Through maintenance of the NFκB:IκB-β complex, κB-Ras1 serves as a crucial brake on inflammatory responses and cellular proliferation, preventing conditions that could lead to disease development. The evolutionary significance of these functions becomes evident in the 71% similarity between κB-Ras1 and κB-Ras2, reflecting conservation of their roles in cellular signaling. Through these diverse cellular functions, κB-Ras1 (184C278) antibody provides researchers with a valuable tool for investigating NFκB signaling dynamics and their implications in health and disease.
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κB-Ras1 Antibody (184C278) References:
- Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. | Huxford, T. and Ghosh, G. 2006. Methods Enzymol. 407: 527-34. PMID: 16757350
- FOXO3a turns the tumor necrosis factor receptor signaling towards apoptosis through reciprocal regulation of c-Jun N-terminal kinase and NF-kappaB. | Lee, HY., et al. 2008. Arterioscler Thromb Vasc Biol. 28: 112-20. PMID: 18032780
- Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. | Dieguez-Gonzalez, R., et al. 2009. Ann Rheum Dis. 68: 579-83. PMID: 18434448
- Prognostic significance of kappaB-Ras1 expression in gliomas. | Lin, H., et al. 2012. Med Oncol. 29: 1272-9. PMID: 21302000
- Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner. | Wang, L., et al. 2014. Cell Stem Cell. 15: 51-65. PMID: 24996169
- Bridging the Gap: A Regulator of NF-κB Linking Inflammation and Cancer. | Postler, TS. and Ghosh, S. 2015. J Oral Biosci. 57: 143-147. PMID: 26273209
- RBPJ inhibits the movability of endometrial carcinoma cells by miR-155/NF-κB/ROS pathway. | Xiao, Y., et al. 2019. Onco Targets Ther. 12: 8075-8084. PMID: 31632061
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
κB-Ras1 Antibody (184C278) | sc-52915 | 100 µg/ml | $339.00 |