Molecular structure of JYL-827, CAS Number: 401572-96-1
JYL-827 (CAS 401572-96-1)
Alternate Names:
N-(2-(3,4-dimethylbenzyl)-3-(pivaloyloxy)propyl)-N'-(4-(methylsulfonylamino)benzyl)thiourea
Application:
JYL-827 is a potent VR1 (TRPV1) agonist with reported RTX antagonism
CAS Number:
401572-96-1
Molecular Weight:
519.7
Molecular Formula:
C26H37N3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JYL-827 is a potent TRPV1 agonist. RTX binding affinity (Ki=29.3nM), antagonism (IC50=67nM).
JYL-827 (CAS 401572-96-1) References
- N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor. | Lee, J., et al. 2003. J Med Chem. 46: 3116-26. PMID: 12825950
- High-affinity partial agonists of the vanilloid receptor. | Wang, Y., et al. 2003. Mol Pharmacol. 64: 325-33. PMID: 12869637
- Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity. | Lee, J., et al. 2004. Bioorg Med Chem Lett. 14: 2291-7. PMID: 15081027
- Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. | Pearce, LV., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377: 149-57. PMID: 18259730
- Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level. | Pearce, LV., et al. 2019. Biomol Ther (Seoul). 27: 435-441. PMID: 31302951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JYL-827, 1 mg | sc-202193 | 1 mg | $80.00 | |||
JYL-827, 5 mg | sc-202193A | 5 mg | $320.00 |