Integrin β5/ITGB5 Antibody (4AK): sc-130379
- Integrin β5/ITGB5 Antibody (4AK) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant Integrin β5 of human origin
- recommended for detection of Integrin β5 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin β5/ITGB5 Antibody (4AK). This work is in progress.
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Integrin β5 Antibody (4AK) is a mouse monoclonal IgG1 antibody that detects Integrin β5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Integrin β5 is a crucial component of the integrin family, functioning as a receptor that mediates cell adhesion to the extracellular matrix and plays a significant role in various cellular processes. Integrin β5 is primarily located on the cell surface, where Integrin β5 forms heterodimers with α subunits, such as αv, to create functional integrin receptors. Integrin β5 presence on the cell membrane is vital for facilitating interactions with extracellular matrix components like fibronectin and vitronectin, which are essential for maintaining tissue integrity and promoting cellular signaling pathways. These interactions not only support cell adhesion but also trigger intracellular signaling cascades that influence cell behavior, including migration, proliferation, and survival. Anti-Integrin β5 antibody (4AK) enables researchers to gain insights into the mechanisms of cell adhesion and signaling, which are critical for understanding various physiological and pathological processes, including wound healing, immune responses, and cancer metastasis.
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Integrin β5/ITGB5 Antibody (4AK) References:
- p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration. | Li, Z., et al. 2010. J Biol Chem. 285: 23699-710. PMID: 20507994
- Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways. | Bianchi-Smiraglia, A., et al. 2013. Oncogene. 32: 3049-58. PMID: 22824793
- Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β. | Bianchi-Smiraglia, A., et al. 2013. Cell Cycle. 12: 3377-89. PMID: 24036928
- Integrin-β1, not integrin-β5, mediates osteoblastic differentiation and ECM formation promoted by mechanical tensile strain. | Zeng, Q., et al. 2015. Biol Res. 48: 25. PMID: 25971622
- RNF185-AS1 promotes hepatocellular carcinoma progression through targeting miR-221-5p/integrin β5 axis. | Huang, C., et al. 2021. Life Sci. 267: 118928. PMID: 33358902
- Integrin β5 enhances the malignancy of human colorectal cancer by increasing the TGF-β signaling. | Shi, W., et al. 2021. Anticancer Drugs. 32: 717-726. PMID: 33587354
- Integrin β5 and β7 expression in lenalidomide-resistant multiple myeloma cells. | Hattori, Y., et al. 2022. Int J Hematol. 115: 605-608. PMID: 35194739
- Dichotomous role of integrin-β5 in lung endothelial cells. | Blanchard, N., et al. 2022. Pulm Circ. 12: e12156. PMID: 36438452
- Integrin β5 subunit regulates hyperglycemia-induced vascular endothelial cell apoptosis through FoxO1-mediated macroautophagy. | Lin, X., et al. 2024. Chin Med J (Engl). 137: 565-576. PMID: 37500497
- Integrin β5, a noninvasive diagnostic biomarker, is associated with unfavorable prognosis and immunotherapy efficacy in gastric cancer. | Cheng, Y., et al. 2024. BMC Gastroenterol. 24: 362. PMID: 39394072
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin β5/ITGB5 Antibody (4AK) | sc-130379 | 100 µg/ml | $339.00 |