Integrin β2/ITGB2/CD18 Antibody (2Q822): sc-71399

Integrin β2 Antibody (2Q822) is a mouse monoclonal IgG1 antibody that detects Integrin β2 in human samples through western blotting (non-reducing), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin β2 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Specifically, anti-Integrin β2 antibody (2Q822) recognizes receptors that pair with various α subunits to play a vital role in cell adhesion and signaling. Integrin β2 is predominantly located on the cell surface, where Integrin β2 interacts with ligands in the extracellular matrix, such as Fibronectin and Collagen, as well as with counterreceptors on adjacent cells. This positioning is essential for mediating cellular responses to the extracellular environment, influencing processes such as cell migration, proliferation, and survival. Furthermore, Integrin β2 is involved in the immune response, particularly in leukocyte adhesion and migration, which are critical for effective immune surveillance and response to inflammation. The ability of Integrin β2 to cluster and activate signaling pathways upon ligand binding underscores its importance in maintaining cellular homeostasis and facilitating communication between cells and their environment. Integrin β2 (2Q822) monoclonal antibody serves as an invaluable tool for researchers studying these complex biological processes and the role of integrins in health and disease.

The preferred Integrin β2/ITGB2/CD18 antibody is Integrin β2/ITGB2/CD18 Antibody (CTB104): sc-8420.