Integrin β2/ITGB2/CD18 Antibody (2B2.45): sc-71404

Integrin β2 Antibody (2B2.45) is a rat monoclonal IgG2a antibody that detects Integrin β2 in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin β2 monoclonal antibody (2B2.45) is raised against Integrin β2 from spleen cells of mouse origin. Anti-Integrin β2 antibody (2B2.45) recognizes a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Integrin β2 (2B2.45) antibody pairs with various α subunits to form receptors that play a vital role in cell adhesion and signaling. Integrin β2 is predominantly located on the cell surface, where Integrin β2 interacts with ligands in the extracellular matrix, such as Fibronectin and Collagen, as well as with counterreceptors on adjacent cells. Proper localization of Integrin β2 is essential for facilitating cell-cell and cell-matrix interactions, which are critical for processes like immune response, wound healing, and tissue development. Furthermore, clustering of integrins upon ligand binding activates intracellular signaling pathways that influence cell behavior, including migration, proliferation, and survival. Anti-Integrin β2 antibody (2B2.45) enables researchers to gain insights into the dynamic roles of Integrin β2 in various biological contexts, enhancing understanding of cellular mechanisms and potential therapeutic targets.

The preferred Integrin β2/ITGB2/CD18 antibody is Integrin β2/ITGB2/CD18 Antibody (CTB104): sc-8420.