Integrin αM/CD11b Antibody (LM2/1): sc-65429

Integrin αM Antibody (LM2/1) is a mouse monoclonal IgG1 kappa light chain antibody designed to recognize the I domain of Integrin αM, also known as CD11b, ITGAM, Mac-1 α subunit, and complement component receptor-3 α. Integrin αM monoclonal antibody (LM2/1) is raised against human Integrin αM and demonstrates strong reactivity in immunofluorescence (IF) and flow cytometry (FCM), specifically targeting Integrin αM present on natural killer cells, monocytes, and granulocytes of human origin. Integrin αM is a crucial cell adhesion molecule that forms a heterodimer with Integrin β2, creating the Mac-1 or CR3 complex, which is essential for immune cell adhesion, migration, and phagocytosis of complement-coated particles. A significant aspect of Integrin αM′s functionality is post-translational modification, particularly glycosylation in the I domain, which is vital for proper protein folding, stability, and ligand-binding capabilities. These glycosylation patterns influence Integrin αM′s ability to interact with intracellular adhesion molecules (ICAMs) and other ligands, thereby modulating immune responses and inflammatory processes. Understanding these modifications is critical for researchers studying molecular mechanisms of immune cell trafficking, inflammation, and various pathological conditions where cell adhesion and migration play key roles. Integrin αM (LM2/1) antibody provides a reliable tool for investigating the expression and regulation of Integrin αM, facilitating advancements in immunological research and development of therapeutic strategies targeting immune-related diseases. Anti-Integrin αM antibody (LM2/1) is an indispensable reagent for scientists exploring structural and functional dynamics of Integrin αM, offering precise detection to support significant breakthroughs in understanding immune system functions and dysfunctions.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.