Integrin αM/CD11b Antibody (CC104): sc-101829

Integrin αM Antibody (CC104) is a mouse monoclonal IgG2b antibody designed to target Integrin αM, also known as CD11b, ITGAM, MAC1A, MO1A, and complement component receptor-3 α (CR3α). Integrin αM is a crucial cell adhesion molecule that plays a significant role in the immune system by mediating the adhesion and migration of leukocytes, particularly neutrophils and monocytes, to sites of inflammation. Integrin αM achieves this by binding to cell surface ligands such as intracellular adhesion molecules (ICAMs) and soluble ligands, facilitating the formation of the heterodimeric integrin αM/β2 complex known as Mac-1 or CR3. This complex is essential for the adherence of immune cells to the endothelium and the phagocytosis of complement-coated pathogens, thereby contributing to the body′s defense mechanisms against infections. Anti-Integrin αM antibody (CC104) is specifically raised against the CC1 hybridoma and peripheral blood monocytes of bovine origin, ensuring high reactivity in bovine samples as demonstrated by immunofluorescence (IF) and flow cytometry (FCM) assays. Anti-Integrin αM antibody (CC104) does not cross-react with Integrin αM of ovine origin, providing specificity for bovine studies. By targeting Integrin αM, researchers can effectively investigate its role in immune responses, inflammation, and related pathological conditions, making anti-Integrin αM antibody (CC104) a valuable tool for both basic research and diagnostic applications. Integrin αM antibody (CC104) offers reliable performance and reproducible results, supporting advanced investigations into the molecular mechanisms underlying immune cell function and interaction.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.