Integrin α5/ITGA5/CD49e Antibody (D-9): sc-166666

Integrin α5 Antibody (D-9) is a mouse monoclonal IgG2a antibody that detects Integrin α5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin α5 plays a crucial role in cell adhesion and is primarily located on the cell surface, where Integrin α5 forms heterodimers with the β1 subunit to create the α5β1 integrin receptor. This receptor is essential for binding to extracellular matrix components like fibronectin, which is vital for various cellular processes, including tissue repair, cell migration, and differentiation. Integrin α5 on the cell surface facilitates interaction with the extracellular matrix, promoting cellular signaling pathways that influence cell behavior and function. Furthermore, Integrin α5′s ability to cluster and interact with other integrins enhances signaling capacity, making Integrin α5 a key player in the regulation of cellular responses to the extracellular environment. Anti-Integrin α5 antibody (D-9) is an invaluable tool for researchers studying the dynamics of cell adhesion and signaling in various biological contexts.

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Integrin α5/ITGA5/CD49e Antibody (D-9) References:

1. ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells.  |  Haenssen, KK., et al. 2010. J Cell Sci. 123: 1373-82. PMID: 20332114
2. Regulation of integrin α5 and β4 in normal and scleroderma epidermal keratinocytes.  |  Zhou, J., et al. 2012. Br J Dermatol. 166: 1369-70. PMID: 22568676
3. miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression.  |  Ohyagi-Hara, C., et al. 2013. Am J Pathol. 182: 1876-89. PMID: 23499550
4. Cyclic hydrodynamic pressure induced proliferation of bladder smooth muscle cells via integrin alpha5 and FAK.  |  Wei, TQ., et al. 2014. Physiol Res. 63: 127-34. PMID: 24182341
5. TMPRSS4 regulates levels of integrin α5 in NSCLC through miR-205 activity to promote metastasis.  |  Larzabal, L., et al. 2014. Br J Cancer. 110: 764-74. PMID: 24434435
6. Integrin-α5 promoted the progression of oral squamous cell carcinoma and modulated PI3K/AKT signaling pathway.  |  Fan, QC., et al. 2019. Arch Oral Biol. 101: 85-91. PMID: 30909080
7. Integrin α5 subunit is required for the tumor supportive role of fibroblasts in colorectal adenocarcinoma and serves as a potential stroma prognostic marker.  |  Lu, L., et al. 2019. Mol Oncol. 13: 2697-2714. PMID: 31600854
8. Integrin α5 promotes migration and cisplatin resistance in esophageal squamous cell carcinoma cells.  |  Hou, S., et al. 2019. Am J Cancer Res. 9: 2774-2788. PMID: 31911861
9. Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions.  |  Pantano, F., et al. 2021. Oncogene. 40: 1284-1299. PMID: 33420367
10. Connective tissue growth factor promotes chemotaxis of preosteoblasts through integrin α5 and Ras during tensile force-induced intramembranous osteogenesis.  |  Jiang, W., et al. 2021. Sci Rep. 11: 2368. PMID: 33504916

The preferred Integrin α5/ITGA5/CD49e antibody is Integrin α5/ITGA5/CD49e Antibody (P1D6): sc-13547.