Integrin α4/ITGA4/CD49d Antibody (PS/2): sc-52593
- Integrin α4/ITGA4/CD49d Antibody (PS/2) is a rat monoclonal IgG2b, cited in 2 publications, provided at 200 µg/ml
- recommended for detection of Integrin α4 of mouse, rat and human origin by IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin α4/ITGA4/CD49d Antibody (PS/2). This work is in progress.
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Integrin α4 Antibody (PS/2) is a rat monoclonal IgG2b light chain antibody that detects Integrin α4 in mouse, rat, and human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin α4 plays a crucial role in cell adhesion and migration by mediating interactions between cells and the extracellular matrix, as well as between cells themselves. Integrin α4 is primarily located on the cell surface, where Integrin α4 forms heterodimers with the β1 or β7 subunits, allowing binding to ligands such as fibronectin and vascular cell adhesion molecule-1 (VCAM-1). Integrin α4 localization on the cell membrane is vital for function in leukocyte trafficking and homing to sites of inflammation, which is essential for immune responses and tissue repair. Furthermore, Integrin α4 engagement with ligands triggers intracellular signaling pathways that influence cell behavior, including survival, proliferation, and differentiation. Anti-Integrin α4 antibody (PS/2) enables researchers to gain insights into the mechanisms of cell adhesion and migration, which are fundamental processes in both normal physiology and various pathological conditions, including cancer metastasis and autoimmune diseases.
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Integrin α4/ITGA4/CD49d Antibody (PS/2) References:
- An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. | Deakin, NO., et al. 2009. J Cell Sci. 122: 1654-64. PMID: 19401330
- Aberrant DNA methylation of integrin alpha4: a potential novel role for metastasis of cholangiocarcinoma. | Uhm, KO., et al. 2010. J Cancer Res Clin Oncol. 136: 187-94. PMID: 19655168
- Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. | Hsieh, YT., et al. 2013. Blood. 121: 1814-8. PMID: 23319569
- Aberrant DNA methylation of integrin α4 in human breast cancer. | Do, SI., et al. 2014. Tumour Biol. 35: 7079-84. PMID: 24756760
- Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells. | Hsieh, YT., et al. 2014. Leukemia. 28: 2101-4. PMID: 24903479
- Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer. | Mostafavi-Pour, Z., et al. 2015. Pathol Oncol Res. 21: 921-7. PMID: 25743258
- Integrin α4 is involved in the regulation of glioma-induced motility of bone marrow mesenchymal stem cells. | Ma, JC., et al. 2015. Oncol Rep. 34: 779-86. PMID: 26034878
- Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models. | Kihara, Y., et al. 2015. Ann Clin Transl Neurol. 2: 978-83. PMID: 26478898
- Serosal Cavities Contain Two Populations of Innate-like integrin α4highCD4+ T Cells, Integrin α4β1+α6β1+α4β7- and α4β1+α6β1-α4β7+ Cells. | Yang, JI., et al. 2017. Immune Netw. 17: 392-401. PMID: 29302252
- Integrin α4 mediates ATDC5 cell adhesion to negatively charged synthetic polymer hydrogel leading to chondrogenic differentiation. | Hashimoto, D., et al. 2020. Biochem Biophys Res Commun. 528: 120-126. PMID: 32456794
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin α4/ITGA4/CD49d Antibody (PS/2) | sc-52593 | 200 µg/ml | $322.00 | |||
Integrin α4/ITGA4/CD49d Antibody (PS/2) FITC | sc-52593 FITC | 200 µg/ml | $336.00 | |||
Integrin α4/ITGA4/CD49d Antibody (PS/2) PE | sc-52593 PE | 200 µg/ml | $349.00 |