ILK Antibody (E-2): sc-137221

ILK Antibody (E-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects integrin-linked kinase (ILK) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ILK antibody (E-2) is available in a non-conjugated form, allowing for versatile experimental use. Integrin-linked kinase plays a crucial role in cellular signaling and is primarily located at the cell membrane, where ILK interacts with integrins, which are essential for cell adhesion and communication with the extracellular matrix. This localization enables ILK to mediate the transduction of signals that influence various biological processes, including cell growth, differentiation, and migration. ILK interaction with integrins facilitates the assembly of the cytoskeleton and promotes cellular responses to external stimuli, thereby impacting tissue development and repair. ILK has been implicated in tumorigenesis, as expression levels can influence the behavior of cancer cells, making ILK a significant target for research in cancer biology. Anti-ILK antibody (E-2) enables researchers to gain insights into the functional dynamics of ILK and its role in both normal physiology and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ILK Antibody (E-2) References:

1. The role of integrin-linked kinase (ILK) in cancer progression.  |  Persad, S. and Dedhar, S. 2003. Cancer Metastasis Rev. 22: 375-84. PMID: 12884912
2. The PINCH-ILK-parvin complexes: assembly, functions and regulation.  |  Wu, C. 2004. Biochim Biophys Acta. 1692: 55-62. PMID: 15246679
3. ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling.  |  Qin, J. and Wu, C. 2012. Curr Opin Cell Biol. 24: 607-13. PMID: 22763012
4. Implicating ILK in inflammation.  |  Plow, EF. and Simon, DI. 2020. Blood. 136: 2097-2099. PMID: 33152089
5. Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology.  |  Martucci, N., et al. 2021. Gene Expr. 20: 201-207. PMID: 33482930
6. Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILK.  |  Masi, I., et al. 2021. Cell Rep. 34: 108800. PMID: 33657382
7. Characterization of pseudokinase ILK-mediated actin assembly.  |  Vaynberg, J. and Qin, J. 2022. Methods Enzymol. 667: 123-146. PMID: 35525540
8. Extracellular vesicles from iPsc-MSCs alleviate chemotherapy-induced mouse ovarian damage via the ILK-PI3K/AKT pathway.  |  Cao, RC., et al. 2023. Zool Res. 44: 620-635. PMID: 36866625
9. MCP-1 exerts the inflammatory response via ILK activation during endometriosis pathogenesis.  |  Soni, UK., et al. 2024. Life Sci. 353: 122902. PMID: 39004271
10. RNF19A inhibits bladder cancer progression by regulating ILK ubiquitination and inactivating the AKT/mTOR signalling pathway.  |  Deng, H., et al. 2024. Biol Direct. 19: 102. PMID: 39508245

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ILK Antibody (E-2) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-ILK Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ILK Antibody (E-2) Specifications

Alternate Product Name: Integrin linked kinase (ILK)

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 434-452

Epitope Target: ILK

Epitope Species: human

Product Reactivity/Detection: ILK-1 and ILK-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for ILK Antibody (E-2): P: Blocking Peptide

The preferred ILK antibody is ILK Antibody (65.1): sc-20019.