IL-22Rα1 Antibody (3-RE40): sc-134366

IL-22Rα1 Antibody (3-RE40) is a mouse monoclonal IgG3 kappa light chain antibody that detects the IL-22R alpha 1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-22R alpha 1 antibody (3-RE40) is available as the non-conjugated format. IL-22Rα1 protein, also known as interleukin 22 receptor, alpha 1, is a crucial component of the immune response, functioning as a receptor for the cytokines IL-20, IL-22, and IL-24. IL-22Rα1 protein is primarily located on the surface of various cells, including those in the lung, liver, kidney, colon, and pancreas, as well as in keratinocytes of both normal and psoriatic skin. IL-22Rα1 expression on these cells is vital for mediating inflammatory responses, particularly in conditions such as chronic rhinosinusitis and multiple sclerosis, where IL-22Rα1 enhances innate immune responses. Structurally, IL-22Rα1 protein is a single-pass type I membrane protein consisting of 574 amino acids and contains two fibronectin type-III domains, which are important for interaction with other proteins and for maintaining stability and function. The gene encoding IL-22Rα1 is located on human chromosome 1p36.11, and defects in this receptor can lead to significant immune dysregulation, highlighting IL-22Rα1′s importance in maintaining immune homeostasis.

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IL-22Rα1 Antibody (3-RE40) References:

1. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.  |  Xie, MH., et al. 2000. J Biol Chem. 275: 31335-9. PMID: 10875937
2. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes.  |  Kotenko, SV., et al. 2001. J Biol Chem. 276: 2725-32. PMID: 11035029
3. IL-22 increases the innate immunity of tissues.  |  Wolk, K., et al. 2004. Immunity. 21: 241-54. PMID: 15308104
4. Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism.  |  Bleicher, L., et al. 2008. FEBS Lett. 582: 2985-92. PMID: 18675809
5. IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22.  |  Wu, PW., et al. 2008. J Mol Biol. 382: 1168-83. PMID: 18675824
6. Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22.  |  de Moura, PR., et al. 2009. FEBS Lett. 583: 1072-7. PMID: 19285080
7. Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis.  |  Endam, LM., et al. 2009. Otolaryngol Head Neck Surg. 140: 741-7. PMID: 19393422

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-22Rα1 Antibody (3-RE40) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-22Rα1 Antibody (3-RE40) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-22Rα1 Antibody (3-RE40) Specifications

Alternate Product Name: IL-22Rα1

Product Clone Name: 3-RE40

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 19-575

Epitope Target: IL-22Rα1

Epitope Species: human

Product Reactivity/Detection: IL-22Rα1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for IL-22Rα1 Antibody (3-RE40): N/A