IGSF11 Antibody (H-9): sc-393816

IGSF11 Antibody (H-9) is a mouse monoclonal IgG3 kappa light chain antibody that detects IGSF11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IGSF11 antibody (H-9) is available as a non-conjugated format. IGSF11, also known as brain and testis-specific immunoglobulin superfamily protein or V-set and immunoglobulin domain-containing protein 3, consists of 431 amino acids and is expressed in three isoforms. IGSF11 is predominantly localized to the cellular membrane as a single-pass membrane protein and is highly expressed in the testis and ovary, with additional expression in the brain, kidney, and skeletal muscle. IGSF11 includes V-type and C2-type immunoglobulin domains, which are crucial for molecular recognition and facilitate cell-cell adhesion through both homophilic and heterophilic interactions. These interactions are particularly significant for neuronal cell communication, such as neuron-neuron and neuron-glia interactions, which are vital for the development and functionality of the central nervous system. IGSF11 is implicated in the interactions between Sertoli cells and spermatocytes, playing a key role during spermatogenesis. IGSF11 gene is often upregulated in gastric cancer, and high expression in various human tumors suggests potential as a target for immunotherapy, making IGSF11 (H-9) antibody a valuable tool for research and therapeutic applications.

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IGSF11 Antibody (H-9) References:

1. Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis.  |  Suzu, S., et al. 2002. Biochem Biophys Res Commun. 296: 1215-21. PMID: 12207903
2. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM.  |  Katoh, M. and Katoh, M. 2003. Int J Oncol. 23: 525-31. PMID: 12851705
3. CLMP, a novel member of the CTX family and a new component of epithelial tight junctions.  |  Raschperger, E., et al. 2004. J Biol Chem. 279: 796-804. PMID: 14573622
4. BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule.  |  Harada, H., et al. 2005. J Cell Physiol. 204: 919-26. PMID: 15795899
5. Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas.  |  Watanabe, T., et al. 2005. Cancer Sci. 96: 498-506. PMID: 16108831

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGSF11 Antibody (H-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IGSF11 Antibody (H-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGSF11 Antibody (H-9) Specifications

Alternate Product Name: IGSF11

Product Clone Name: H-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 21-38

Epitope Target: IGSF11

Epitope Species: human

Product Reactivity/Detection: IGSF11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IGSF11 Antibody (H-9): P: Blocking Peptide