GRB2 Antibody (C-6): sc-365619
- GRB2 Antibody (C-6) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 189-217 at the C-terminus of GRB2 of human origin
- recommended for detection of GRB2 p25 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See GRB2 (C-7): sc-8034 for GRB2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP is the preferred secondary detection reagent for GRB2 Antibody (C-6) for WB applications. This reagent is now offered in a bundle with GRB2 Antibody (C-6) (see ordering information below).
QUICK LINKS
GRB2 Antibody (C-6) is a mouse monoclonal IgG2b antibody that detects GRB2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GRB2 antibody (C-6) plays a crucial role in cellular signaling pathways, particularly in the regulation of growth factor-induced activation of Ras proteins, which are pivotal in controlling cell proliferation, differentiation, and survival. GRB2 (C-6) antibody targets a protein primarily located in the cytoplasm that interacts with activated receptor molecules, such as the epidermal growth factor receptor (EGFR), through its SH2 domain. This interaction is essential for the transduction of signals from the cell surface to the nucleus, thereby influencing gene expression and cellular responses to external stimuli. The structural integrity of GRB2, including its SH2 and SH3 domains, is vital for its function, as these domains facilitate the binding to phosphorylated tyrosine residues and other signaling proteins, forming a complex that ultimately activates downstream signaling pathways. Understanding the role of GRB2 in these processes is important for elucidating mechanisms of cellular communication and the potential implications in various diseases, including cancer, where aberrant signaling can lead to uncontrolled cell growth.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRB2 Antibody (C-6) | sc-365619 | 200 µg/ml | $322.00 | |||
GRB2 Antibody (C-6): m-IgG2b BP-HRP Bundle | sc-548558 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRB2 (C-6) Neutralizing Peptide | sc-365619 P | 100 µg/0.5 ml | $69.00 |