Glutathione reductase Antibody (A-5): sc-133136

Glutathione reductase Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects glutathione reductase in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-glutathione reductase antibody (A-5) plays a crucial role in studying cellular defense against oxidative stress by detecting proteins that maintain high levels of reduced glutathione, which is essential for detoxifying reactive oxygen species and protecting cellular components from damage. Glutathione reductase monoclonal antibody (A-5) targets proteins primarily located in the cytosol and mitochondria, where glutathione reductase catalyzes the reduction of oxidized glutathione, thereby ensuring a balanced redox state within the cell. The ability of glutathione reductase to form a disulfide-linked homodimer and its redox-active disulfide bond at the active site are vital for its enzymatic function, highlighting its importance in cellular metabolism and signaling pathways. Glutathione reductase (A-5) antibody serves as an invaluable tool for researchers studying oxidative stress, redox biology, and related diseases, providing reliable detection and characterization of this essential protein in various experimental settings.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Glutathione reductase Antibody (A-5) References:

1. The role of glutathione reductase and related enzymes on cellular redox homoeostasis network.  |  Couto, N., et al. 2016. Free Radic Biol Med. 95: 27-42. PMID: 26923386
2. Targeting thioredoxin glutathione reductase as a potential antischistosomal drug target.  |  Eweas, AF. and Allam, G. 2018. Mol Biochem Parasitol. 225: 94-102. PMID: 30291946
3. Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis.  |  Jobbagy, S., et al. 2019. Redox Biol. 21: 101050. PMID: 30654300
4. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice.  |  Robbins, ME., et al. 2021. Redox Biol. 38: 101797. PMID: 33254076
5. Glutathione Reductase-Sensitive Polymeric Micelles for Controlled Drug Delivery on Arthritic Diseases.  |  Lima, AC., et al. 2021. ACS Biomater Sci Eng. 7: 3229-3241. PMID: 34161062
6. Glutathione reductase system changes in HTLV-1 infected patients.  |  Ehtiati, S., et al. 2022. Virusdisease. 33: 32-38. PMID: 35493755
7. The Role of Glutathione Reductase in Influenza Infection.  |  Hong, KS., et al. 2022. Am J Respir Cell Mol Biol. 67: 438-445. PMID: 35767671
8. SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase.  |  Xu, FL., et al. 2023. Cell Death Dis. 14: 22. PMID: 36635256
9. Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo.  |  Petukhova, VZ., et al. 2023. Nat Commun. 14: 3737. PMID: 37349300
10. Glutathione Reductase Expression and Its Prognostic Significance in Colon Cancer.  |  Brzozowa-Zasada, M., et al. 2024. Int J Mol Sci. 25: PMID: 38256170

The preferred Glutathione reductase antibody is Glutathione reductase Antibody (C-10): sc-133245.