Gliotoxin (CAS 67-99-2)

Estado de Materia :

Solid

Forma Derivada :

Gladiocladium fimbriatum

Solubilidad :

Soluble in DMSO (10 mg/ml), methanol (10 mg/ml), chloroform (10 mg/ml), DMF, and Pyridine.

Almacenamiento :

Store at -20° C

Punto de ebullición :

699.72° C at 760 mmHg

Densidad :

1.75 g/cm³

Indice de Refracción :

n²⁰_D 1.81

IC50 :

geranylgeranyltransferase I: IC₅₀ = 17 µM; farnesyltransferase: IC₅₀ = 80 µM; FTase: IC₅₀ = 1.1 µM; A549 (Lung carcinoma cells): IC₅₀ = 3 nM (Homo sapiens); Trypanosoma brucei brucei: IC₅₀ = 10 nM (Trypanosoma brucei brucei); HUVEC₅₀ (Umbilical vein endothelial cells): IC₅₀ = 123 nM (Homo sapiens); CEM (T-cell leukemia): IC₅₀ = 150 nM (Homo sapiens); Acetolactate synthase catalytic subunit, mitochondrial: IC₅₀ = 200 nM (Saccharomyces cerevisiae S288c); Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit: IC₅₀ = 1100 nM (Homo sapiens); HeLa (Cervical adenocarcinoma cells): IC₅₀ = 2450 nM (Homo sapiens); Candida albicans: IC₅₀ = 3100 nM (Candida albicans); Plasmodium falciparum (isolate K1 / Thailand): IC₅₀ = 3600 nM (Plasmodium falciparum K1); Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit: IC₅₀ = 17000 nM (Homo sapiens); Mycothiol S-conjugate amidase: IC₅₀ = 50000 nM (Mycobacterium tuberculosis); Protein farnesyltransferase

WGK Alemania :

3

RTECS :

KB4725000

PubChem CID :

Indice de Merck :

14: 4441

Número MDL :

MFCD00058534

Registro Beilstein :

50675

SMILES :

CN1C(=O)C23CC4=CC=C[C@H](O)C4N2C(=O)C1(CO)SS3