Gliotoxin, a toxic epipolythiodioxopiperazine metabolite, has been shown to be an immunosuppressive mycotoxin. This agent displays a capacity to induce macrophagocytic, thymocytic, splenocytic, and mesenteric lymph node cell apoptosis and inhibit transcription factor NF-κB activation. Mechanistic studies suggest that this inhibition is done via a suppression of proteasome-mediated degradation of IκB-α. Additional research reports that Gliotoxin is capable of down-regulating inflammation and suppressing TNFα IL-1α and mRNA expression. Gliotoxin is an inhibitor of Farnesyl Transferase and GGTase. Gliotoxin is an inhibitor of 20S Proteasome. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the regulation of transcriptional activity by writing epigenetic marks.
1. Pahl, H.L., et al. 1996. J. Exp. Med. 183: 1829-1840. PMID: 8666939 2. Kroll, M., et al. 1999. Chem. Biol. 6: 689-698. PMID: 10508680 3. Ward, C., et al. 1999. J. Biol. Chem. 274: 4309-4318. PMID: 9933632 4. Herfarth, H., et al. 2000. Clin. Exp. Immunol. 120: 59-65. PMID: 10759764 5. Sugui, J.A., et al. 2007. Eukaryotic Cell. 6: 1562-1569. PMID: 17601876
Estado de Materia
Soluble in DMSO (10 mg/ml), methanol (10 mg/ml), chloroform (10 mg/ml), DMF, and Pyridine.
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