GGL Antibody (153-81D4): sc-59548
- GGL Antibody (153-81D4) is a mouse monoclonal IgM GGL antibody provided at 100 µl ascites
- raised against synthetic epsilon-(gamma-glutamyl) lysine
- recommended for detection of gamma-glutamyl lysine by WB, IF and IHC(P); non cross-reactive with either lysine or glutamine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GGL Antibody (153-81D4). This work is in progress.
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GGL Antibody (153-81D4) is a mouse monoclonal IgM antibody that detects GGL protein by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-GGL antibody (153-81D4) is available as a non-conjugated format. GGL protein plays a crucial role in forming N epsilon-(gamma-glutamyl) lysine bonds through tissue transglutaminase activity. These bonds contribute to extracellular matrix (ECM) structural integrity by providing proteolysis resistance, influencing apoptosis, cellular differentiation, and matrix stabilization. GGL protein is predominantly localized in the nucleus and releases from blood cells during coagulation, highlighting GGL protein′s importance in ECM accumulation and tissue fibrosis. Abnormal GGL protein levels have been linked to human diabetic nephropathy, a condition characterized by progressive glomerulosclerosis and renal interstitial fibrosis, underscoring GGL protein′s relevance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GGL Antibody (153-81D4) References:
- Increases in renal epsilon-(gamma-glutamyl)-lysine crosslinks result from compartment-specific changes in tissue transglutaminase in early experimental diabetic nephropathy: pathologic implications. | Skill, NJ., et al. 2001. Lab Invest. 81: 705-16. PMID: 11351042
- Competitive enzyme-linked immonosorbent assay for N epsilon gamma-glutamyl lysine. | Sárvári, M., et al. 2002. Anal Biochem. 311: 187-90. PMID: 12470680
- N epsilon(gamma-glutamyl)lysine crosslinks in the blood clot of the horseshoe crab, Limulus polyphemus. | Wilson, J., et al. 1992. Biochem Biophys Res Commun. 188: 655-61. PMID: 1445311
- Elevated epsilon-(gamma-glutamyl)lysine in human diabetic nephropathy results from increased expression and cellular release of tissue transglutaminase. | El Nahas, AM., et al. 2004. Nephron Clin Pract. 97: c108-17. PMID: 15292688
- Localization of tissue transglutaminase and N (epsilon)-(gamma) -glutamyl lysine in duodenal cucosa during the development of mucosal atrophy in coeliac disease. | Sakly, W., et al. 2005. Virchows Arch. 446: 613-8. PMID: 15891906
- Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size. | Boisvert, WA., et al. 2006. Arterioscler Thromb Vasc Biol. 26: 563-9. PMID: 16410462
- Increase in extracellular cross-linking by tissue transglutaminase and reduction in expression of MMP-9 contribute differentially to focal segmental glomerulosclerosis in rats. | Liu, S., et al. 2006. Mol Cell Biochem. 284: 9-17. PMID: 16477388
- Characterization of a microbial transglutaminase cross-linked type II collagen scaffold. | O Halloran, DM., et al. 2006. Tissue Eng. 12: 1467-74. PMID: 16846344
- Assays for the measurement of tissue transglutaminase (type II) mediated protein crosslinking via epsilon-(gamma-glutamyl) lysine and N',N'-bis (gamma-glutamyl) polyamine linkages using biotin labelled casein. | Lilley, GR., et al. 1997. J Biochem Biophys Methods. 34: 31-43. PMID: 9089382
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GGL Antibody (153-81D4) | sc-59548 | 100 µl ascites | $322.00 |